Coccidioidomycosis: efficacy of new agents and future prospects

被引：23
作者：
Deresinski, SC [1 ]
机构：
[1] Stanford Univ, Dept Med, Stanford, CA 94305 USA
来源：
CURRENT OPINION IN INFECTIOUS DISEASES | 2001年 / 14卷 / 06期
关键词：
D O I：
10.1097/00001432-200112000-00005
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Recent studies have contributed to our understanding of risk factors for severe and potentially life-threatening infections with Coccidioides immitis, allowing a more rational approach to initiation of antifungal therapy for this infection, as well as determining its intensity and duration. A large randomized trial found that itraconazole and fluconazole had similar efficacies in the treatment of progressive nonmeningeal coccidioidomycosis. An animal model of coccidioidal meningitis suggested potential efficacy of systemically administered liposomal amphotericin B. Investigational agents that have activity against C. immitis include posaconazole, voriconazole, caspofungin, and sordarin derivatives. Curr Opin Infect Dis 14:693-696, (C) 2001 Lippincott Williams & Wilkins.
引用
收藏
页码：693 / 696
页数：4
相关论文
共 13 条
[1]  
BAUER R, 1995, 35 INT C ANT AG CHEM
[2]  
CALDWELL J, 1996, 5 INT C COCC 24 27 A
[3]  
CATANZARO A, 2000, 40 INT C ANT AG CHEM
[4]   Efficacies of sordarin derivatives GM193663, GM211676, and GM237354 in a murine model of systemic coccidioidomycosis [J].
Clemons, KV ;
Stevens, DA .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (07) :1874-1877
[5]  
CLEMONS KV, 2000, 40 INT C ANT AG CHEM
[6]   Comparison of oral fluconazole and itraconazole for progressive, nonmeningeal coccidioidomycosis - A randomized, double-blind trial [J].
Galgiani, JN ;
Catanzaro, A ;
Cloud, GA ;
Johnson, RH ;
Williams, PL ;
Mirels, LF ;
Nassar, F ;
Lutz, JE ;
Stevens, DA ;
Sharkey, PK ;
Singh, VR ;
Larsen, RA ;
Delgado, KL ;
Flanigan, C ;
Rinaldi, MG .
ANNALS OF INTERNAL MEDICINE, 2000, 133 (09) :676-686
[7]   Practice guidelines for the treatment of coccidioidomycosis [J].
Galgiani, JN ;
Ampel, NM ;
Catanzaro, A ;
Johnson, RH ;
Stevens, DA ;
Williams, PL .
CLINICAL INFECTIOUS DISEASES, 2000, 30 (04) :658-661
[8]   Correlation between antifungal susceptibilities of Coccidioides immitis in vitro and antifungal treatment with caspofungin in a mouse model [J].
González, GM ;
Tijerina, R ;
Najvar, LK ;
Bocanegra, R ;
Luther, M ;
Rinaldi, MG ;
Graybill, JR .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (06) :1854-1859
[9]   Antifungal activity of the new azole UK-109, 496 (voriconazole) [J].
Kappe, R .
MYCOSES, 1999, 42 :83-86
[10]   In vitro activities of voriconazole, itraconazole, and amphotericin B against Blastomyces dermatitidis, Coccidioides immitis and Histoplasma capsulatum [J].
Li, RK ;
Ciblak, MA ;
Nordoff, N ;
Pasarell, L ;
Warnock, DW ;
McGinnis, MR .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (06) :1734-1736
12