Mechanistic links between COPD and lung cancer

被引：325

作者：

Houghton, A. McGarry ^{[1
,2
]}

机构：

[1] Univ Washington, Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98109 USA

[2] Univ Washington, Div Pulm & Crit Care, Seattle, WA 98109 USA

来源：

NATURE REVIEWS CANCER | 2013年 / 13卷 / 04期

关键词：

OBSTRUCTIVE PULMONARY-DISEASE; SMOKE-INDUCED EMPHYSEMA; AIR-FLOW OBSTRUCTION; MICROSOMAL EPOXIDE HYDROLASE; ABERRANT PROMOTER METHYLATION; GENOME-WIDE ASSOCIATION; NEUTROPHIL ELASTASE; TOBACCO-SMOKE; MATRIX METALLOPROTEINASES; MACROPHAGE POLARIZATION;

D O I：

10.1038/nrc3477

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Numerous epidemiological studies have consistently linked the presence of chronic obstructive pulmonary disease (COPD) to the development of lung cancer, independently of cigarette smoking dosage. The mechanistic explanation for this remains poorly understood. Progress towards uncovering this link has been hampered by the heterogeneous nature of the two disorders: each is characterized by multiple sub-phenotypes of disease. In this Review, I discuss the nature of the link between the two diseases and consider specific mechanisms that operate in both COPD and lung cancer, some of which might represent either chemopreventive or chemotherapeutic targets.

引用

页码：233 / 245

页数：13

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