A New Thiopurine S-Methyltransferase Haplotype Associated With Intolerance to Azathioprine

被引：15

作者：

Colleoni, Lara ^{[1
]}

Kapetis, Dimos ^{[1
]}

Maggi, Lorenzo ^{[1
]}

Camera, Giorgia ^{[1
]}

Canioni, Eleonora ^{[1
]}

Cavalcante, Paola ^{[1
]}

de Rosbo, Nicole Kerlero ^{[1
]}

Baggi, Fulvio ^{[1
]}

Antozzi, Carlo ^{[1
]}

Confalonieri, Paolo ^{[1
]}

Mantegazza, Renato ^{[1
]}

Bernasconi, Pia ^{[1
]}

机构：

[1] Fdn IRCCS Neurol Inst Carlo Besta, Milan, Italy

来源：

JOURNAL OF CLINICAL PHARMACOLOGY | 2013年 / 53卷 / 01期

关键词：

thiopurine S-S; azathioprine; single nucleotide polymorphism; haplotype; myasthenia gravis; INFLAMMATORY-BOWEL-DISEASE; MYASTHENIA-GRAVIS; ALLELIC VARIANTS; PHARMACOGENETICS; GENE; 6-MERCAPTOPURINE; POLYMORPHISMS; MECHANISM; DRUGS;

D O I：

10.1177/0091270011435989

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The authors have analyzed single nucleotide polymorphisms in the thiopurine S-methyltransferase (TPMT) gene in the context of efficacy and toxicity of azathioprine (AZA) to determine possible genotype-phenotype correlations between TPMT allelic variants and response to AZA treatment in 76 Italian patients with myasthenia gravis. They confirm known intronic and exonic TPMT polymorphisms that do not correlate with AZA responses and demonstrate a novel intronic polymorphism in a patient intolerant to AZA. Most importantly, they show that of the 22 AZA-intolerant patients, all 5 who carried mutations of the intolerance-linked haplotype TPMT*3A also carried the intronic T140+114A (rs3931660), all 3 mutations being part of a new haplotype designated TMPT*3E. TPMT*3E was not observed in unresponsive or responsive patients. The association of TPMT*3E with AZA intolerance and its frequency must be ascertained in larger, ethnically different cohorts. Nevertheless, in view of the highly significant association (Psim = 0.0026) between TPMT*3E and AZA intolerance in the study, this new haplotype should be taken into consideration in pharmacogenetic profiling for AZA.

引用

页码：67 / 74

页数：8

共 40 条

[21] PHARMACOGENETICS OF ACUTE AZATHIOPRINE TOXICITY - RELATIONSHIP TO THIOPURINE METHYLTRANSFERASE GENETIC-POLYMORPHISM [J].