Synthesis of functionalized triazolo[1,5-a]pyrimidine derivatives

被引:8
作者
Chechina, Natal'ya V. [1 ]
Kolos, Nadezhda N. [1 ]
Omelchenko, Irina V. [2 ]
Musatov, Vladimir I. [2 ]
机构
[1] Kharkov Natl Univ, 4 Svobody Sq, UA-61022 Kharkov, Ukraine
[2] Natl Acad Sci Ukraine, STC Inst Single Crystals, 60 Nauky Ave, UA-61072 Kharkov, Ukraine
关键词
acetoacetic ester; acetylacetone; arylglyoxal hydrates; 4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidines; 1H-1,2,4-triazol-5-amine; Biginelli-like reaction; three-component condensation;
D O I
10.1007/s10593-018-2230-1
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
New triazolo[1,5-a]pyrimidines containing aroyl and acetyl or ester groups in the pyrimidine ring were synthesized in a process related to the Biginelli-like reaction, using hydrates of arylglyoxals, beta-dicarbonyl compounds, and 1H-1,2,4-triazol-5-amine. Reaction was carried out in either sequential or one-pot procedure.
引用
收藏
页码:58 / 62
页数:5
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