Quinone-enhanced sonochemical production of nitric oxide from s-nitrosoglutathione

被引：3

作者：

Alegria, Antonio E. ^{[1
]}

Dejesus-Andino, Francisco J. ^{[1
]}

Sanchez-Cruz, Pedro ^{[1
]}

机构：

[1] Univ Puerto Rico, Dept Chem, CUH Stn, Humacao, PR 00791 USA

来源：

ULTRASONICS SONOCHEMISTRY | 2009年 / 16卷 / 01期

关键词：

Sonochemical reduction; Sonochemistry; Quinones; Superoxide; Nitrosothiol; Nitric oxide; SATURATED AQUEOUS-SOLUTIONS; FREE-RADICAL FORMATION; XANTHINE-OXIDASE; ASCORBIC-ACID; ULTRASOUND; NITROSOTHIOLS; NO; GLUTATHIONE; REDUCTION; DECOMPOSITION;

D O I：

10.1016/j.ultsonch.2008.05.009

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

Sonolysis at 75 kHz of argon- and air-saturated aqueous solutions at pH 7.4 containing s-nitrosogluthathione (GSNO) enhances the production rate of nitric oxide (NO). The quinones, anthraquinone-2-sulfonate (AQ2S) and anthraquinone-2,7-disulfonate (AQ27S) further enhance the NO production over that produced in quinone-depleted sonicated solutions. In contrast, the hydrophobic quinones juglone (JQ) and 1,4-naphthoquinone (NQ) inhibit ultrasound-induced No detection as compared to quinone-depleted solutions. Larger sonolytical decomposition of the hydrophobic quinones NQ and JQ, as compared to AQ2S and AQ27S, is detected which correlates with a larger production of pyrolysis-derived carbon-centered radicals. Reaction of those radicals with NO could explain NQ and JQ inhibition. This work suggests that sulfonated quinones could be used to enhance NO release from GSNO in tissues undergoing ultrasound irradiation. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：190 / 196

页数：7

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