Future therapy for non-alcoholic fatty liver disease

被引：37

作者：

Issa, Danny ^{[1
]}

Patel, Vaishali ^{[1
]}

Sanyal, Arun J. ^{[1
]}

机构：

[1] Virginia Commonwealth Univ, Sch Med, Dept Internal Med, Div Gastroenterol Hepatol & Nutr, Richmond, VA 23284 USA

来源：

LIVER INTERNATIONAL | 2018年 / 38卷

关键词：

cirrhosis; fibrosis; nonalcoholic fatty liver disease; nonalcoholic fatty liver disease activity score; nonalcoholic steatohepatitis; ACTIVATED PROTEIN-KINASE; CORONARY-HEART-DISEASE; VITAMIN-E; NATURAL-HISTORY; ALCOHOL-CONSUMPTION; INSULIN-RESISTANCE; WEIGHT-LOSS; THIAZOLIDINEDIONE USE; URSODEOXYCHOLIC ACID; HEPATIC STEATOSIS;

D O I：

10.1111/liv.13676

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Non-alcoholic fatty liver disease is a leading cause of chronic liver disease and can lead to cirrhosis, hepatocellular cancer and end stage liver disease. It is also associated with increased cardiovascular and cancer related morbidity and mortality. The pathogenesis of non-alcoholic fatty liver disease includes metabolic stress to the liver associated with insulin resistance with downstream cell stress from reactive oxygen species and unfolded protein response with activation of inflammatory and fibrotic pathways. There are currently no approved therapies for non-alcoholic fatty liver disease. This review summarizes ongoing efforts to establish the treatment of non-alcoholic steatohepatitis the progressive form of non-alcoholic fatty liver disease. Therapies are currently directed towards improving the metabolic status of the liver, cell stress, apoptosis, inflammation or fibrosis. Several agents are now in pivotal trials and it is expected that the first therapies will be approved in 2-3years.

引用

页码：56 / 63

页数：8

共 84 条

[41]

Laurin J, 1996, HEPATOLOGY, V23, P1464

[42] Effect of Vitamin E or Metformin for Treatment of Nonalcoholic Fatty Liver Disease in Children and Adolescents The TONIC Randomized Controlled Trial [J].

Lavine, Joel E. ;

Schwimmer, Jeffrey B. ;

Van Natta, Mark L. ;

Molleston, Jean P. ;

Murray, Karen F. ;

Rosenthal, Philip ;

Abrams, Stephanie H. ;

Scheimann, Ann O. ;

Sanyal, Arun J. ;

Chalasani, Naga ;

Tonascia, James ;

Uenalp, Aynur ;

Clark, Jeanne M. ;

Brunt, Elizabeth M. ;

Kleiner, David E. ;

Hoofnagle, Jay H. ;

Robuck, Patricia R. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2011, 305 (16) :1659-1668

[43] Obesity alters gut microbial ecology [J].

Ley, RE ;

Bäckhed, F ;

Turnbaugh, P ;

Lozupone, CA ;

Knight, RD ;

Gordon, JI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (31) :11070-11075

[44] Metformin reverses fatty liver disease in obese, leptin-deficient mice [J].

Lin, HZ ;

Yang, SQ ;

Chuckaree, C ;

Kuhajda, F ;

Ronnet, G ;

Diehl, AM .

NATURE MEDICINE, 2000, 6 (09) :998-1003

[45] Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: Results of a randomized trial [J].

Lindor, KD ;

Kowdley, KV ;

Heathcote, EJ ;

Harrison, ME ;

Jorgensen, R ;

Angulo, P ;

Lymp, JF ;

Burgart, L ;

Colin, P .

HEPATOLOGY, 2004, 39 (03) :770-778

[46] Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: A randomized controlled trial [J].

Loguercio, Carmela ;

Andreone, Pietro ;

Brisc, Ciprian ;

Brisc, Michaela Cristina ;

Bugianesi, Elisabetta ;

Chiaramonte, Maria ;

Cursaro, Carmela ;

Danila, Mirela ;

de Sio, Ilario ;

Floreani, Annarosa ;

Freni, Maria Antonietta ;

Grieco, Antonio ;

Groppo, Marzia ;

Lazzari, Roberta ;

Lobello, Salvatore ;

Lorefice, Elisabetta ;

Margotti, Marzia ;

Miele, Luca ;

Milani, Stefano ;

Okolicsanyi, Lajos ;

Palasciano, Giuseppe ;

Portincasa, Piero ;

Saltarelli, Patrizia ;

Smedile, Antonina ;

Somalvico, Francesco ;

Spadaro, Aldo ;

Sporea, Ioan ;

Sorrentino, Paolo ;

Vecchione, Raffaela ;

Tuccillo, Concetta ;

Blanco, Camillo Del Vecchio ;

Federico, Alessandro .

FREE RADICAL BIOLOGY AND MEDICINE, 2012, 52 (09) :1658-1665

[47]

Loomba R, 2016, LIV M NOV 11 15

[48] Ezetimibe for the Treatment of Nonalcoholic Steatohepatitis: Assessment by Novel Magnetic Resonance Imaging and Magnetic Resonance Elastography in a Randomized Trial (MOZART Trial) [J].

Loomba, Rohit ;

Sirlin, Claude B. ;

Ang, Brandon ;

Bettencourt, Ricki ;

Jain, Rashmi ;

Salotti, Joanie ;

Soaft, Linda ;

Hooker, Jonathan ;

Kono, Yuko ;

Bhatt, Archana ;

Hernandez, Laura ;

Phirum Nguyen ;

Noureddin, Mazen ;

Haufe, William ;

Hooker, Catherine ;

Yin, Meng ;

Ehman, Richard ;

Lin, Grace Y. ;

Valasek, Mark A. ;

Brenner, David A. ;

Richards, Lisa .

HEPATOLOGY, 2015, 61 (04) :1239-1250

[49] Liver abnormalities in severely obese subjects:: Effect of drastic weight loss after gastroplasty [J].

Luyckx, FH ;

Desaive, C ;

Thiry, A ;

Dewé, W ;

Scheen, AJ ;

Gielen, JE ;

Lefèbvre, PJ .

INTERNATIONAL JOURNAL OF OBESITY, 1998, 22 (03) :222-226

[50] The role of thiazolidinediones in non-alcoholic steatohepatitis - A systematic review and meta analysis [J].

Mahady, Suzanne E. ;

Webster, Angela C. ;

Walker, Sarah ;

Sanyal, Arun ;

George, Jacob .

JOURNAL OF HEPATOLOGY, 2011, 55 (06) :1383-1390

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