Strongly increased levels of fibrinogen elastase degradation products in patients with ischemic stroke

被引：6

作者：

de Lau, Lonneke M. L. ^{[2
]}

Cheung, Elim Y. L. ^{[1
]}

Kluft, Cornelis ^{[3
]}

Leebeek, Frank W. G. ^{[1
]}

Meijer, Piet ^{[3
]}

Laterveer, Ria ^{[3
]}

Dippel, Diederik W. J. ^{[2
]}

de Maat, Moniek P. M. ^{[1
]}

机构：

[1] Erasmus MC, Dept Haematol, NL-3000 CA Rotterdam, Netherlands

[2] Erasmus MC, Dept Neurol, NL-3000 CA Rotterdam, Netherlands

[3] TNO Qual Life, Gaubius Inst, Leiden, Netherlands

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2008年 / 143卷 / 05期

关键词：

stroke; fibrinogen degradation products; leucocyte activation; elastase; epidemiology;

D O I：

10.1111/j.1365-2141.2008.07395.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ischemic stroke is associated with leucocyte activation. Activated leucocytes release elastase, an enzyme that can degrade fibrinogen. Fibrinogen elastase degradation products (FgEDP) may serve as a specific marker of elastase proteolytic activity. In a case-control study of 111 ischemic stroke patients and 119 controls, significantly higher FgEDP levels were observed in cases than in controls, both in the acute phase and in the convalescent phase. Results were only slightly affected by adjustment for cardiovascular risk factors, C-reactive protein and fibrinogen. Our findings suggest that FgEDP might be involved in the pathogenesis of stroke.

引用

页码：734 / 737

页数：4

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