Structure-activity relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers

被引：22

作者：

Kenwood, Brandon M. ^{[1
]}

Calderone, Joseph A. ^{[2
,3
]}

Taddeo, Evan P. ^{[1
]}

Hoehn, Kyle L. ^{[1
,4
,5
,6
,7
]}

Santos, Webster L. ^{[2
,3
]}

机构：

[1] Univ Virginia, Dept Pharmacol, Charlottesville, VA 22908 USA

[2] Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA

[3] Virginia Tech, Virginia Tech Ctr Drug Discovery, Blacksburg, VA 24061 USA

[4] Univ Virginia, Dept Med, Charlottesville, VA 22908 USA

[5] Univ Virginia, Cardiovasc Res Ctr, Charlottesville, VA 22908 USA

[6] Univ Virginia, Emily Cour Clin Canc Ctr, Charlottesville, VA 22908 USA

[7] Univ New S Wales, Dept Biotechnol & Biomol Sci, Kensington, NSW 2052, Australia

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2015年 / 25卷 / 21期

关键词：

Mitochondrial uncoupler; Mitochondrial bioenergetics; Protonophore; Structure-activity relationships; Pyrazines; SUBSTITUTED PHENOLS; INSULIN-RESISTANCE; PLASMA-MEMBRANE; MECHANISM; PROTON; MODEL; FCCP; CELLS;

D O I：

10.1016/j.bmcl.2015.06.040

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chemical mitochondrial uncouplers are lipophilic weak acids that transport protons into the mitochondrial matrix via a pathway that is independent of ATP synthase, thereby uncoupling nutrient oxidation from ATP production. These uncouplers have potential for the treatment of diseases such as obesity, Parkinson's disease, and aging. We have previously identified a novel mitochondrial protonophore, named BAM15, which stimulates mitochondrial respiration across a broad dosing range compared to carbonyl cyanide p-trifluoromethoxyphenylhydrazone (FCCP). Herein, we report our investigations on the structure-activity relationship profile of BAM15. Our studies demonstrate the importance of the furazan, pyrazine, and aniline rings as well as pKa in maintaining its effective protonophore activity. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：4858 / 4861

页数：4

共 25 条

[21]

Starchenkov I. B., 1997, CHEM HETEROCYCL COMP, V33, P1219, DOI DOI 10.1007/BF02290874

[22]

SUN XC, 1992, J BIOL CHEM, V267, P19147

[23] Cellular bioenergetics as a target for obesity therapy [J].

Tseng, Yu-Hua ;

Cypess, Aaron M. ;

Kahn, C. Ronald .

NATURE REVIEWS DRUG DISCOVERY, 2010, 9 (06) :465-481

[24] Mitochondrial uncoupling agents antagonize rotenone actions in rat substantia nigra dopamine neurons [J].

Wu, Yan-Na ;

Munhall, Adam C. ;

Johnson, Steven W. .

BRAIN RESEARCH, 2011, 1395 :86-93

[25] Synthesis of bulky and electron-rich MOP-type ligands and their applications in palladium-catalyzed C-N bond formation [J].

Xie, Xiaomin ;

Zhang, Tony Y. ;

Zhang, Zhaoguo .

JOURNAL OF ORGANIC CHEMISTRY, 2006, 71 (17) :6522-6529

← 1 2 3 →