Helical poly(arginine) mimics with superior cell-penetrating and molecular transporting properties

被引：132

作者：

Tang, Haoyu ^{[1
]}

Yin, Lichen ^{[1
]}

Kim, Kyung Hoon ^{[1
]}

Cheng, Jianjun ^{[1
]}

机构：

[1] Univ Illinois, Dept Mat Sci & Engn, Urbana, IL 61801 USA

来源：

CHEMICAL SCIENCE | 2013年 / 4卷 / 10期

基金：

美国国家科学基金会;

关键词：

PERMEABLE MINIATURE PROTEINS; NONVIRAL GENE DELIVERY; IN-VITRO; PEPTIDE; ARGININE; SIRNA; DOMAIN; INTERNALIZATION; NANOPARTICLES; TRANSFECTION;

D O I：

10.1039/c3sc51328a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Poly(arginine) mimics bearing long hydrophobic side chains adopt a stable helical conformation and exhibit helix-related cell-penetrating properties. Elongating the polypeptide backbone length and increasing side chain hydrophobicity further increase the helicities of poly(arginine) mimics. These helical poly(arginine) mimics show superior cell membrane permeability up to two orders of magnitude higher than that of HIV-TAT peptide and excellent DNA and siRNA delivery efficiencies in various mammalian cells.

引用

页码：3839 / 3844

页数：6

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