The role of mitochondria in age-related hearing loss

被引：50
作者：
Chen, Hengchao [1 ]
Tang, Jianguo [1 ]
机构：
[1] Zhejiang Univ, Dept Otolaryngol Head & Neck Surg, Sir Run Run Shaw Hosp, Coll Med, Hangzhou 310016, Zhejiang, Peoples R China
来源：
BIOGERONTOLOGY | 2014年 / 15卷 / 01期
关键词：
Age-related hearing loss; Mitochondria; Oxidative stress; Mitochondrial DNA; HUMAN TEMPORAL BONE; DNA COMMON DELETION; RADICAL SCAVENGERS; OXIDATIVE STRESS; C57BL/6J MICE; PRESBYCUSIS; IMPAIRMENT; EXPRESSION; ANTIOXIDANTS; PREVALENCE;
D O I：
10.1007/s10522-013-9475-y
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Age-related hearing loss (ARHL), the hearing loss associated with aging, is a vital problem in present society. The severity of hearing loss is possibly associated with the degeneration of cochlear cells. Mitochondria play a key role in the energy supply, cellular redox homeostasis, signaling, and regulation of programmed cell death. In this review, we focus on the central role of mitochondria in ARHL. The mitochondrial redox imbalance and mitochondrial DNA mutation might collaboratively involve in the process of cochlear senescence in response to the aging stress. Subsequent responses, including alteration of mitochondrial biogenesis, mitophagy, apoptosis and paraptosis, participate in the aging process from different respects.
引用
收藏
页码：13 / 19
页数：7
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