Nucleophilic difluoromethylation and difluoromethylenation of aldehydes and ketones using diethyl difluoromethylphosphonate

被引:48
作者
Beier, Petr [1 ]
Alexandrova, Anastasia V. [1 ]
Zibinsky, Mikhail [2 ]
Prakash, G. K. Surya [2 ]
机构
[1] Acad Sci Czech Republic, Inst Organ Chem & Biochem, CR-16610 Prague 6, Czech Republic
[2] Univ So Calif, Dept Chem, Loker Hydrocarbon Res Inst, Los Angeles, CA 90089 USA
关键词
Difluoromethylation; Difluoromethylenation; Phosphonate; Nucleophilic addition;
D O I
10.1016/j.tet.2008.10.006
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
New methodology for difluoromethylation and difluoromethylenation of aldehydes and ketones based On nucleophilic fluorination using diethyl difluoromethylphosphonate (1) was developed (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码:10977 / 10985
页数:9
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