Synthesis and Biological Activity of 3-(2-Oxoalkylidene)-3,4-Dihydro-2H-1,4-Benzoxazines

被引：5

作者：

Zykova, S. S. ^{[1
]}

Karmanova, O. G. ^{[2
]}

机构：

[1] Perm Penal Serv Inst, Perm 614012, Russia

[2] State Univ, Moscow Inst Phys & Technol, Moscow 117303, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2015年 / 49卷 / 06期

关键词：

1,3,4,6-tetracarbonyl compounds; 3-(2-oxoalkylidene)-3,4-dihydro-2H-1,4-benzoxazin-2-ones; 2-alkanoylmethyl-2-hydroxy-3,4-dihydro-2H-1,4-benzoxazines; Escherichia coli BW 25113; antihypoxant activity; antioxidant activity; antiradical activity; acute toxicity;

D O I：

10.1007/s11094-015-1286-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A simple and convenient method for the synthesis of biologically active 3-(2-oxoalkylidene)-3,4-dihydro-2H-1,4-benzoxazin-2-ones was proposed. The structures of the synthesized compounds were established using NMR and IR spectroscopy and mass spectrometry. It was established that the synthesized compounds possessed antioxidant, antiradical, and strong antihypoxant activity and exhibited low acute toxicity, which allowed the search for new antioxidants and antihypoxants among benzoxazines to continue.

引用

页码：362 / 366

页数：5

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