New air-stable catalysts for general and efficient Suzuki-Miyaura cross-coupling reactions of heteroaryl chlorides

被引：166

作者：

Guram, AS ^{[1
]}

King, AO ^{[1
]}

Allen, JG ^{[1
]}

Wang, XH ^{[1
]}

Schenkel, LB ^{[1
]}

Chan, J ^{[1
]}

Bunel, EE ^{[1
]}

Faul, MM ^{[1
]}

Larsen, RD ^{[1
]}

Martinelli, MJ ^{[1
]}

Reider, PJ ^{[1
]}

机构：

[1] Amgen Inc, Chem Res & Discovery, Thousand Oaks, CA 91320 USA

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 09期

关键词：

D O I：

10.1021/ol060268g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New air-stable PdCl2{(PBu2)-Bu-1(p-R-Ph)}(2) (R = H, NMe2, CF3,) complexes represent simple, general, and efficient catalysts for the Suzuki-Miyaura cross-coupling reactions of aryl halides including five-membered heteroaryl halides and heteroatom-substituted six-membered heteroaryl chlorides with a diverse range of arylboronic acids. High product yields (89-99% isolated yields) and turn-over-numbers (10000 TON) are observed.

引用

页码：1787 / 1789

页数：3

共 34 条

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