T cell-based gene therapy of cancer

被引：16
|
作者：
Gill, Saar
Kalos, Michael
机构：
[1] Univ Penn, Perelman Sch Med, Dept Med, Div Hematol Oncol, Philadelphia, PA 19104 USA
[2] Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
来源：
TRANSLATIONAL RESEARCH | 2013年 / 161卷 / 04期
关键词：
PERIPHERAL-BLOOD LYMPHOCYTES; ACTIVATED KILLER-CELLS; ADOPTIVE TRANSFER; ANTIGEN-RECEPTOR; EX-VIVO; CHIMERIC RECEPTORS; IMMUNE-RESPONSES; RETROVIRAL TRANSDUCTION; CLINICAL-RESPONSES; CD28; COSTIMULATION;
D O I：
10.1016/j.trsl.2012.11.002
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Adoptive immunotherapy using gene engineered T cells is a promising and rapidly evolving field, and the ability to engineer T cells to manifest desired phenotypes and functions has become a practical reality. In this review, we describe and summarize current thought about gene engineering of T cells. We focus on the identified requirements for the successful application of T cell based immunotherapy and discuss gene-therapy based strategies that address these requirements and have the potential to enhance the successful implementation of this promising approach to treat cancer. (Translational Research 2013;161:365-379)
引用
收藏
页码：365 / 379
页数：15
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