Synthesis of thiosemicarbazones derived from N-(4-hippuric acid) thiosemicarbazide and different carbonyl compounds as antimicrobial agents

被引：64
作者：
El-Sharief, Marwa A. M. Sh. [1 ]
Abbas, Samir Y. [2 ]
El-Bayouki, Khairy A. M. [2 ]
El-Gammal, Eman W. [3 ]
机构：
[1] Natl Res Ctr, Appl Organ Chem Dept, Cairo, Egypt
[2] Natl Res Ctr, Organometall & Organometalloid Chem Dept, Cairo, Egypt
[3] Natl Res Ctr, Dept Chem Nat & Microbial Prod, Cairo, Egypt
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2013年 / 67卷
关键词：
Thiosemicarbazones; Hippuric acid; Thiosemicarbazide; Carbonyl compounds; Antimicrobial activity; ANTI-HIV ACTIVITY; PALLADIUM(II) COMPLEXES; ANTIBACTERIAL; DERIVATIVES; MOIETY;
D O I：
10.1016/j.ejmech.2013.06.031
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
New series of thiosemicarbazone derivatives incorporating a hippuric acid moiety have been synthesized through the reaction of N-(4-hippuric acid)thiosemicarbazide with various carbonyl compounds such as aldehydes, ketones and cyclic ketones. The synthesized compounds were tested against bacterial and fungal strains. Most of compounds, such as 2-(4-(2-(4-fluorobenzylidene)hydrazinecarbothioamido) benzamido)acetic acid showed significant antibacterial and antifungal activities. These compounds comprise a new class of promising broad-spectrum antibacterial and antifungal agents. (C) 2013 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：263 / 268
页数：6
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