Differentiation of epidermal keratinocytes is dependent on glucosylceramide:ceramide processing
被引:45
作者:
Amen, Nicole
论文数: 0引用数: 0
h-index: 0
机构:
German Canc Res Ctr, Div Cellular & Mol Pathol, D-69120 Heidelberg, GermanyGerman Canc Res Ctr, Div Cellular & Mol Pathol, D-69120 Heidelberg, Germany
Amen, Nicole
[1
]
Mathow, Daniel
论文数: 0引用数: 0
h-index: 0
机构:
German Canc Res Ctr, Div Cellular & Mol Pathol, D-69120 Heidelberg, GermanyGerman Canc Res Ctr, Div Cellular & Mol Pathol, D-69120 Heidelberg, Germany
Mathow, Daniel
[1
]
Rabionet, Mariona
论文数: 0引用数: 0
h-index: 0
机构:
German Canc Res Ctr, Div Cellular & Mol Pathol, D-69120 Heidelberg, Germany
German Canc Res Ctr, D-69120 Heidelberg, GermanyGerman Canc Res Ctr, Div Cellular & Mol Pathol, D-69120 Heidelberg, Germany
Rabionet, Mariona
[1
,2
]
Sandhoff, Roger
论文数: 0引用数: 0
h-index: 0
机构:
German Canc Res Ctr, Div Cellular & Mol Pathol, D-69120 Heidelberg, Germany
German Canc Res Ctr, D-69120 Heidelberg, GermanyGerman Canc Res Ctr, Div Cellular & Mol Pathol, D-69120 Heidelberg, Germany
Sandhoff, Roger
[1
,2
]
Langbein, Lutz
论文数: 0引用数: 0
h-index: 0
机构:
German Canc Res Ctr, D-69120 Heidelberg, GermanyGerman Canc Res Ctr, Div Cellular & Mol Pathol, D-69120 Heidelberg, Germany
Langbein, Lutz
[2
]
Gretz, Norbert
论文数: 0引用数: 0
h-index: 0
机构:
Heidelberg Univ, Med Res Ctr Mannheim, Mannheim, GermanyGerman Canc Res Ctr, Div Cellular & Mol Pathol, D-69120 Heidelberg, Germany
Gretz, Norbert
[3
]
Jaeckel, Carsten
论文数: 0引用数: 0
h-index: 0
机构:
LMU Univ Munich, Univ Hosp Munich, Munich, GermanyGerman Canc Res Ctr, Div Cellular & Mol Pathol, D-69120 Heidelberg, Germany
Jaeckel, Carsten
[4
]
Groene, Hermann-Josef
论文数: 0引用数: 0
h-index: 0
机构:
German Canc Res Ctr, Div Cellular & Mol Pathol, D-69120 Heidelberg, GermanyGerman Canc Res Ctr, Div Cellular & Mol Pathol, D-69120 Heidelberg, Germany
Groene, Hermann-Josef
[1
]
Jennemann, Richard
论文数: 0引用数: 0
h-index: 0
机构:
German Canc Res Ctr, Div Cellular & Mol Pathol, D-69120 Heidelberg, GermanyGerman Canc Res Ctr, Div Cellular & Mol Pathol, D-69120 Heidelberg, Germany
Jennemann, Richard
[1
]
机构:
[1] German Canc Res Ctr, Div Cellular & Mol Pathol, D-69120 Heidelberg, Germany
[2] German Canc Res Ctr, D-69120 Heidelberg, Germany
[3] Heidelberg Univ, Med Res Ctr Mannheim, Mannheim, Germany
Skin barrier function is primarily assigned to the outer epidermal layer, the stratum corneum (SC), mainly composed of corneocytes and lipid-enriched extracellular matrix. Epidermal ceramides (Cers) are essential barrier lipids, containing ultra-long-chain (ULC) fatty acids (FAs) with a unique ?-hydroxy group, which is necessary for binding to corneocyte proteins. In the SC, Cers are believed to derive from glucosylated intermediates, namely glucosylceramides (GlcCers), as surmised from human Gauchers disease and related mouse models. Tamoxifen (TAM)-induced deletion of the endogenous GlcCer-synthesizing enzyme UDP-glucose:ceramide glucosyltransferase (UGCG) in keratin K14-positive cells resulted in epidermal GlcCer depletion. Although free extractable Cers were elevated in total epidermis and as well in SC, protein-bound Cers decreased significantly in Ugcg(f/fK14CreERT2) mice, indicating glucosylation to be required for regular Cer processing as well as arrangement and extrusion of lipid lamellae. The almost complete loss of protein-bound Cers led to a disruption of the water permeability barrier (WPB). UGCG-deficient mice developed an ichthyosis-like skin phenotype marked by impaired keratinocyte differentiation associated with delayed wound healing. Gene expression profiling of Ugcg-mutant skin revealed a subset of differentially expressed genes involved in lipid signaling and epidermal differentiation/proliferation, correlating to human skin diseases such as psoriasis and atopic dermatitis. Peroxisome proliferator-activated receptor beta/delta (PPAR/), a Cer-sensitive transcription factor was identified as potential mediator of the altered gene sets.
机构:
Radboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, NetherlandsRadboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, Netherlands
Bergboer, Judith G. M.
;
Tjabringa, Geuranne S.
论文数: 0引用数: 0
h-index: 0
机构:
Radboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, NetherlandsRadboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, Netherlands
Tjabringa, Geuranne S.
;
Kamsteeg, Marijke
论文数: 0引用数: 0
h-index: 0
机构:
Radboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, NetherlandsRadboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, Netherlands
Kamsteeg, Marijke
;
van Vlijmen-Willems, Ivonne M. J. J.
论文数: 0引用数: 0
h-index: 0
机构:
Radboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, NetherlandsRadboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, Netherlands
van Vlijmen-Willems, Ivonne M. J. J.
;
Rodijk-Olthuis, Diana
论文数: 0引用数: 0
h-index: 0
机构:
Radboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, NetherlandsRadboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, Netherlands
Rodijk-Olthuis, Diana
;
Jansen, Patrick A. M.
论文数: 0引用数: 0
h-index: 0
机构:
Radboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, NetherlandsRadboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, Netherlands
Jansen, Patrick A. M.
;
Thuret, Jean-Yves
论文数: 0引用数: 0
h-index: 0
机构:
Li Ka Shing Ctr, Cambridge Res Inst, Canc Res UK, Cambridge, EnglandRadboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, Netherlands
Thuret, Jean-Yves
;
Narita, Masashi
论文数: 0引用数: 0
h-index: 0
机构:
Li Ka Shing Ctr, Cambridge Res Inst, Canc Res UK, Cambridge, EnglandRadboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, Netherlands
Narita, Masashi
;
Ishida-Yamamoto, Akemi
论文数: 0引用数: 0
h-index: 0
机构:
Asahikawa Med Univ, Dept Dermatol, Asahikawa, Hokkaido, JapanRadboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, Netherlands
Ishida-Yamamoto, Akemi
;
Zeeuwen, Patrick L. J. M.
论文数: 0引用数: 0
h-index: 0
机构:
Radboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, NetherlandsRadboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, Netherlands
Zeeuwen, Patrick L. J. M.
;
Schalkwijk, Joost
论文数: 0引用数: 0
h-index: 0
机构:
Radboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, NetherlandsRadboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, Netherlands
机构:Univ Roma Tor Vergata, Dept Expt Med, Biochem Lab, IDI IRCCS, I-00133 Rome, Italy
Candi, E
;
Schmidt, R
论文数: 0引用数: 0
h-index: 0
机构:Univ Roma Tor Vergata, Dept Expt Med, Biochem Lab, IDI IRCCS, I-00133 Rome, Italy
Schmidt, R
;
Melino, G
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma Tor Vergata, Dept Expt Med, Biochem Lab, IDI IRCCS, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Expt Med, Biochem Lab, IDI IRCCS, I-00133 Rome, Italy
机构:
Univ Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, England
Sheffield Childrens Hosp, Paediat Dermatol Clin, Sheffield, S Yorkshire, EnglandUniv Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, England
Cork, Michael J.
;
Danby, Simon G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, EnglandUniv Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, England
Danby, Simon G.
;
Vasilopoulos, Yiannis
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, EnglandUniv Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, England
Vasilopoulos, Yiannis
;
Hadgraft, Jonathan
论文数: 0引用数: 0
h-index: 0
机构:
Univ London, Sch Pharm, London WC1N 1AX, EnglandUniv Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, England
Hadgraft, Jonathan
;
Lane, Majella E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ London, Sch Pharm, London WC1N 1AX, EnglandUniv Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, England
Lane, Majella E.
;
Moustafa, Manar
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, England
Sheffield Childrens Hosp, Paediat Dermatol Clin, Sheffield, S Yorkshire, EnglandUniv Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, England
Moustafa, Manar
;
Guy, Richard H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, EnglandUniv Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, England
Guy, Richard H.
;
MacGowan, Alice L.
论文数: 0引用数: 0
h-index: 0
机构:
York Pharma R&D Ltd, Sheffield, S Yorkshire, EnglandUniv Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, England
MacGowan, Alice L.
;
Tazi-Ahnini, Rachid
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, EnglandUniv Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, England
Tazi-Ahnini, Rachid
;
Ward, Simon J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, EnglandUniv Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, England
机构:
Radboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, NetherlandsRadboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, Netherlands
Bergboer, Judith G. M.
;
Tjabringa, Geuranne S.
论文数: 0引用数: 0
h-index: 0
机构:
Radboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, NetherlandsRadboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, Netherlands
Tjabringa, Geuranne S.
;
Kamsteeg, Marijke
论文数: 0引用数: 0
h-index: 0
机构:
Radboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, NetherlandsRadboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, Netherlands
Kamsteeg, Marijke
;
van Vlijmen-Willems, Ivonne M. J. J.
论文数: 0引用数: 0
h-index: 0
机构:
Radboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, NetherlandsRadboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, Netherlands
van Vlijmen-Willems, Ivonne M. J. J.
;
Rodijk-Olthuis, Diana
论文数: 0引用数: 0
h-index: 0
机构:
Radboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, NetherlandsRadboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, Netherlands
Rodijk-Olthuis, Diana
;
Jansen, Patrick A. M.
论文数: 0引用数: 0
h-index: 0
机构:
Radboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, NetherlandsRadboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, Netherlands
Jansen, Patrick A. M.
;
Thuret, Jean-Yves
论文数: 0引用数: 0
h-index: 0
机构:
Li Ka Shing Ctr, Cambridge Res Inst, Canc Res UK, Cambridge, EnglandRadboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, Netherlands
Thuret, Jean-Yves
;
Narita, Masashi
论文数: 0引用数: 0
h-index: 0
机构:
Li Ka Shing Ctr, Cambridge Res Inst, Canc Res UK, Cambridge, EnglandRadboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, Netherlands
Narita, Masashi
;
Ishida-Yamamoto, Akemi
论文数: 0引用数: 0
h-index: 0
机构:
Asahikawa Med Univ, Dept Dermatol, Asahikawa, Hokkaido, JapanRadboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, Netherlands
Ishida-Yamamoto, Akemi
;
Zeeuwen, Patrick L. J. M.
论文数: 0引用数: 0
h-index: 0
机构:
Radboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, NetherlandsRadboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, Netherlands
Zeeuwen, Patrick L. J. M.
;
Schalkwijk, Joost
论文数: 0引用数: 0
h-index: 0
机构:
Radboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, NetherlandsRadboud Univ Nijmegen, Med Ctr, Dept Dermatol, Nijmegen Ctr Mol Life Sci, NL-6500 HB Nijmegen, Netherlands
机构:Univ Roma Tor Vergata, Dept Expt Med, Biochem Lab, IDI IRCCS, I-00133 Rome, Italy
Candi, E
;
Schmidt, R
论文数: 0引用数: 0
h-index: 0
机构:Univ Roma Tor Vergata, Dept Expt Med, Biochem Lab, IDI IRCCS, I-00133 Rome, Italy
Schmidt, R
;
Melino, G
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma Tor Vergata, Dept Expt Med, Biochem Lab, IDI IRCCS, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Expt Med, Biochem Lab, IDI IRCCS, I-00133 Rome, Italy
机构:
Univ Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, England
Sheffield Childrens Hosp, Paediat Dermatol Clin, Sheffield, S Yorkshire, EnglandUniv Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, England
Cork, Michael J.
;
Danby, Simon G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, EnglandUniv Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, England
Danby, Simon G.
;
Vasilopoulos, Yiannis
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, EnglandUniv Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, England
Vasilopoulos, Yiannis
;
Hadgraft, Jonathan
论文数: 0引用数: 0
h-index: 0
机构:
Univ London, Sch Pharm, London WC1N 1AX, EnglandUniv Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, England
Hadgraft, Jonathan
;
Lane, Majella E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ London, Sch Pharm, London WC1N 1AX, EnglandUniv Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, England
Lane, Majella E.
;
Moustafa, Manar
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, England
Sheffield Childrens Hosp, Paediat Dermatol Clin, Sheffield, S Yorkshire, EnglandUniv Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, England
Moustafa, Manar
;
Guy, Richard H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, EnglandUniv Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, England
Guy, Richard H.
;
MacGowan, Alice L.
论文数: 0引用数: 0
h-index: 0
机构:
York Pharma R&D Ltd, Sheffield, S Yorkshire, EnglandUniv Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, England
MacGowan, Alice L.
;
Tazi-Ahnini, Rachid
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, EnglandUniv Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, England
Tazi-Ahnini, Rachid
;
Ward, Simon J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, EnglandUniv Sheffield, Sch Med & Biomed Sci, Acad Unit Biomed Genet Dermatol, Sheffield S10 2RX, S Yorkshire, England