Prognostic values of preoperative platelet-to-lymphocyte ratio, albumin and hemoglobin in patients with non-metastatic colon cancer

被引：27
作者：
Li, Zhigui [1 ]
Xu, Zhaofen [2 ]
Huang, Yuqian [1 ]
Zhao, Rui [1 ]
Cui, Yaping [1 ]
Zhou, Yong [1 ]
Wu, Xiaoting [1 ]
机构：
[1] Sichuan Univ, West China Hosp, Dept Gastrointestinal Surg, Chengdu 610041, Sichuan, Peoples R China
[2] Second Peoples Hosp, Dept Pathol, Neijiang 641000, Sichuan, Peoples R China
来源：
CANCER MANAGEMENT AND RESEARCH | 2019年 / 11卷
关键词：
platelet-to-lymphocyte ratio; albumin; hemoglobin; colon cancer; prognosis; COLORECTAL-CANCER; SUPERIOR PREDICTOR; TUMOR OXYGENATION; MONOCYTE RATIO; GROWTH-FACTOR; SURVIVAL; INFLAMMATION; IMPACT; CELLS;
D O I：
10.2147/CMAR.S191432
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Purpose: Preoperative platelet-to-monocyte ratio (PLR), albumin and hemoglobin are suggested prognostic indicators in various malignancies. However, the prognostic values of PLR, albumin and hemoglobin remain elusive. The objective of the present study was to evaluate the prognostic values of PLR, albumin and hemoglobin in stage I-III colon cancer. Patients and methods: A total of 312 patients with non-metastatic colon cancer undergoing curative resection were enrolled in this study. The prognostic values of PLR, albumin and hemoglobin were identified by receiver operating characteristics, and univariate and multivariate analyses. Results: Univariate analysis revealed that preoperative PLR, albumin and hemoglobin were significantly associated with overall survival (OS) and that preoperative PLR and albumin were significantly associated with progression-free survival (PFS). Multivariate analysis revealed that preoperative PLR was significantly associated with OS. Conclusion: Reduced preoperative PLR was significantly associated with better OS in patients with stage I-III colon cancer. Preoperative PLR was an independent prognostic indictor for OS in patients with colon cancer undergoing curative resection.
引用
收藏
页码：3265 / 3274
页数：10
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