Cutting Edge: Experimentally Induced Immune Activation in Natural Hosts of Simian Immunodeficiency Virus Induces Significant Increases in Viral Replication and CD4+ T Cell Depletion

被引：101

作者：

Pandrea, Ivona ^{[1
,2
,3
]}

Gaufin, Thaidra ^{[1
,2
,4
]}

Brenchley, Jason M. ^{[5
]}

Gautam, Rajeev ^{[1
,2
]}

Moniure, Christopher ^{[1
,2
]}

Gautam, Aarti ^{[1
,2
]}

Coleman, Clint ^{[1
,2
,4
]}

Lackner, Andrew A. ^{[1
,2
,4
]}

Ribeiro, Ruy M. ^{[7
]}

Douek, Daniel C. ^{[6
]}

Apetrei, Cristian ^{[1
,2
,8
]}

机构：

[1] Tulane Natl Primate Res Ctr, Div Comparat Pathol, Covington, LA 70433 USA

[2] Tulane Natl Primate Res Ctr, Div Microbiol, Covington, LA 70433 USA

[3] Tulane Univ, Sch Med, Dept Pathol, New Orleans, LA 70112 USA

[4] Tulane Univ, Sch Med, Dept Microbiol & Immunol, New Orleans, LA 70112 USA

[5] NIAID, Immunopathogenesis Unit, Mol Microbiol Lab, NIH, Bethesda, MD 20892 USA

[6] NIAID, Human Immunol Sect, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

[7] Los Alamos Natl Lab, Los Alamos, NM 87545 USA

[8] Tulane Univ, Sch Publ Hlth, Dept Trop Med, New Orleans, LA 70112 USA

来源：

JOURNAL OF IMMUNOLOGY | 2008年 / 181卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.4049/jimmunol.181.10.6687

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chronically SIVagm-infected African green monkeys (AGMs) have a remarkably stable nonpathogenic disease course, with levels of immune activation in chronic SIVagm infection similar to those observed in uninfected monkeys and with stable viral loads for long periods of time. In vivo administration of LPS or an IL-2/diphtheria toxin fusion protein (Ontak) to chronically SIVagm-infected AGMs triggered increases in immune activation and subsequently of viral replication and depletion of intestinal CD4(+) T cells. Our study indicates that circulating microbial products can increase viral replication by inducing immune activation and increasing the number of viral target cells, thus demonstrating that immune activation and T cell proliferation are key factors in AIDS pathogenesis. The Journal of Immunology, 2008, 181: 6687-6691.

引用

页码：6687 / 6691

页数：5

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