Effects of non-contingent cocaine on 3alpha-androstanediol. I. Disruption of male sexual behavior

被引:4
作者
Kohtz, Amy S. [1 ]
Walf, Alicia A. [1 ,5 ]
Frye, Cheryl A. [1 ,2 ,3 ,4 ]
机构
[1] SUNY Albany, Dept Psychol, 1400 Washington Ave, Albany, NY 12222 USA
[2] SUNY Albany, Biol Sci, Albany, NY 12222 USA
[3] SUNY Albany, Ctr Neurosci, Albany, NY 12222 USA
[4] SUNY Albany, Ctr Life Sci Res, Albany, NY 12222 USA
[5] Rensselaer Polytech Inst, Dept Cognit Sci, Troy, NY USA
关键词
Androgens; 5; alpha-androstane-17; beta; 3; alpha-diol; Cocaine; Neurosteroids; Mating; Testosterone; INDUCED LOCOMOTOR-ACTIVITY; VENTRAL TEGMENTAL AREA; MALE-RATS; NEUROCHEMICAL RESPONSES; EXTRACELLULAR DOPAMINE; ERECTILE DYSFUNCTION; ANDROGEN MODULATION; TESTOSTERONE LEVELS; NUCLEUS-ACCUMBENS; 3-ALPHA-ANDROSTANEDIOL;
D O I
10.1016/j.physbeh.2017.12.017
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
One of the hallmarks of drug abuse is a reduction in the salience of, and motivation for, natural rewards, such as mating. The effects of psychostimulants on male sexual interest and performance are conflicting; use of psychostimulants can produce increases in risky sexual behaviors but have detrimental effects on sexual ability. We hypothesize that these conflicting effects on sexual behavior are due to interactions between cocaine and androgens, such as testosterone and its neuroactive metabolite, 3 alpha-androstanediol (3 alpha-diol). Male rats were administered saline or cocaine (5, 10, or 20 mg/kg, i.p.). Motor behavior was observed in the first 30 min following drug-administration, and then sexual responding was assessed for 15 min. Levels of androgens (testosterone, 3 alpha-diol, and testosterone's aromatized metabolite, estradiol) were measured in circulation and brain regions (frontal cortex, hippocampus, hypothalamus/striatum (hypo/str), and midbrain). Cocaine had no effect on measures of sexual interest (i.e. anogenital investigation). However, cocaine had substantial effects on consummatory sexual behaviors, such as the latency to mount/intromit and the number of sexual contacts. Frontal cortex and hypo/str 3 alpha-diol levels were strongly correlated with consummatory behaviors in saline administered rats; however, this relationship was disrupted by cocaine at all dosages, concomitant with impaired sexual behaviors. Additionally, there was a shift in metabolism at low dosages of cocaine to push testosterone metabolism in the midbrain towards 3 alpha-diol. On the contrary, moderate and high dosages of cocaine shifted testosterone metabolism towards estradiol. These data demonstrate that the association between cortical and hypo/str 3 alpha-diol levels and sexual behavior of male rats is disrupted by non-contingent cocaine and that there may be dose-dependent effects of acute cocaine on androgen metabolism.
引用
收藏
页码:120 / 127
页数:8
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