Cu(OAc)2-Catalyzed Tandem Blaise/Pinner-Type Reaction for One-Pot Synthesis of Pyrimidin-4-ones

被引：31

作者：

Chun, Yu Sung ^{[1
]}

Kim, Ju Hyun ^{[1
]}

Choi, Suh Young ^{[1
]}

Ko, Young Ok ^{[1
]}

Lee, Sang-gi ^{[1
]}

机构：

[1] Ewha Womans Univ, Dept Chem & Nano Sci BK21, Seoul 120750, South Korea

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 24期

关键词：

BLAISE REACTION INTERMEDIATE; EFFICIENT SYNTHESIS; ENAMINOESTERS; ACYLATION; NITRILES; ESTERS;

D O I：

10.1021/ol303153g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel tandem Blaise/Pinner-type reaction for the one-pot synthesis of pyrimidin-4-ones is described. The Blaise reaction intermediate, formed by addition of a Reformatsky reagent to a nitrile, reacted with a second nitrile chemoselectively in the presence of a catalytic amount of Cu(OAc)(2) to afford pyrimidin-4-ones.

引用

页码：6358 / 6361

页数：4

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