Cognitive Outcome After On- and Off-Pump Coronary Artery Bypass Grafting Surgery: A Systematic Review and Meta-Analysis

被引：39

作者：

Kennedy, Ewan D. ^{[1
]}

Choy, Kevin C. C. ^{[1
]}

Alston, R. Peter ^{[2
]}

Chen, Shaoyun ^{[1
]}

Farhan-Alanie, Muhamed M. H. ^{[1
]}

Anderson, Jamie ^{[1
]}

Ang, Yun Lin ^{[1
]}

Moore, Deborah E. ^{[1
]}

MacKenzie, Sam A. ^{[1
]}

Sykes, Robert A. ^{[1
]}

机构：

[1] Univ Edinburgh, Coll Med & Vet Med, Edinburgh EH16 4SB, Midlothian, Scotland

[2] Royal Infirm Edinburgh NHS Trust, Dept Anaesthesia Crit Care & Pain Med, Edinburgh, Midlothian, Scotland

来源：

JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA | 2013年 / 27卷 / 02期

关键词：

cardiopulmonary bypass; coronary disease; coronary artery bypass; off-pump; cognition; coronary artery bypass grafting surgery; on-pump; psychometric tests; HIGH-RISK PATIENTS; ON-PUMP; NEUROCOGNITIVE OUTCOMES; CARDIOPULMONARY BYPASS; BEATING HEART; LIFE OUTCOMES; REVASCULARIZATION; IMPAIRMENT; MORBIDITY; RELEASE;

D O I：

10.1053/j.jvca.2012.11.008

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Objective: The aim of this study was to compare cognition following coronary artery bypass grafting (CABG) surgery with or without cardiopulmonary bypass (CPB) (on- or off-pump). Design: Systematic review and meta-analysis of randomized control trials comparing cognitive outcome in patients undergoing CABG surgery on- or off-pump as assessed by continuous measures from a battery of 7 psychometric tests. Setting: Multi-institutional centers performing CABG surgery. Participants: Patients with coronary artery disease requiring CABG surgery. Interventions: CABG surgery with or without CPB. Measurements and main results: A structured literature search identified 13 randomized control trials that included a total of 2,405 patients. Results from 7 psychometric tests were grouped into early ( <= 3 months) and late (6-12 months) postoperative periods. No significant differences were found between on- and off-pump groups in any of the 7 psychometric tests in either the early (p range 0.21-0.78) or late (p range 0.09-0.93) postoperative period. Conclusion: The results suggested that CPB may not be associated with cognitive decline that is associated with CABG surgery. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：253 / 265

页数：13

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