Nucleic acid nanotechnology for cancer treatment

被引：33

作者：

Jin, Jun-O ^{[1
,2
]}

Kim, Gyurin ^{[3
]}

Hwang, Juyoung ^{[2
]}

Han, Kyung Ho ^{[4
]}

Kwak, Minseok ^{[3
,5
]}

Lee, Peter C. W. ^{[4
]}

机构：

[1] Fudan Univ, Shanghai Med Coll, Shanghai Publ Hlth Clin Ctr, Shanghai 201508, Peoples R China

[2] Yeungnam Univ, Dept Med Biotechnol, Gyongsan 38541, South Korea

[3] Pukyong Natl Univ, Dept Chem, Busan 48513, South Korea

[4] Univ Ulsan, ASAN Med Ctr, Dept Biomed Sci, Coll Med, Seoul 05505, South Korea

[5] DWI Leibniz Inst Interact Mat, D-52056 Aachen, Germany

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2020年 / 1874卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Nucleic acid; Cancer therapy; Nanoparticle; Gene therapy; Immunotherapy; ROLLING CIRCLE AMPLIFICATION; CO-DELIVERY; SIRNA DELIVERY; DENDRITIC CELLS; DRUG-DELIVERY; RECENT PROGRESS; SYNERGISTIC TREATMENT; MULTIDRUG-RESISTANCE; CAMPTOTHECIN PRODRUG; EFFICIENT DELIVERY;

D O I：

10.1016/j.bbcan.2020.188377

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer is one of the most prevalent potentially lethal diseases. With the increase in the number of investigations into the uses of nanotechnology, many nucleic acid (NA)-based nanostructures such as small interfering RNA, microRNA, aptamers, and immune adjuvant NA have been applied to treat cancer. Here, we discuss studies on the applications of NA in cancer treatment, recent research trends, and the limitations and prospects of specific NA-mediated gene therapy and immunotherapy for cancer treatment. The NA structures used for cancer therapy consist only of NA or hybrids comprising organic or inorganic substances integrated with functional NA. We also discuss delivery vehicles for therapeutic NA and anti-cancer agents, and recent trends in NA-based gene therapy and immunotherapy against cancer.

引用

页数：12

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