Role of Cytoreductive Nephrectomy in the Era of Targeted Therapy for Renal Cell Carcinoma

被引：23
作者：
Crispen, Paul L. [1 ]
Blute, Michael L. [2 ]
机构：
[1] Univ Kentucky, Dept Surg, Lexington, KY 40513 USA
[2] Univ Massachusetts, Sch Med, Worcester, MA 01655 USA
来源：
CURRENT UROLOGY REPORTS | 2012年 / 13卷 / 01期
关键词：
Cytoreductive nephrectomy; Surgery; Targeted therapy; Metastasectomy; Renal cell carcinoma; Treatment; Kidney diseases; INTERFERON-ALPHA; SUNITINIB; SURGERY; SURVIVAL; TUMOR;
D O I：
10.1007/s11934-011-0225-x
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
With the advent of targeted therapy for the treatment of metastatic renal cancer, the routine use of cytoreductive nephrectomy has been questioned. However, available data suggest that cytoreductive nephrectomy remains an integral part of treatment in properly selected patients. This review details the rationale for the continued use of cytoreductive nephrectomy in acceptable surgical candidates in the era of targeted therapy.
引用
收藏
页码：38 / 46
页数：9
相关论文
共 44 条
[21]   A Population-based Analysis of the Rate of Cytoreductive Nephrectomy for Metastatic Renal Cell Carcinoma in the United States [J].
Jeldres, Claudio ;
Baillargeon-Gagne, Sara ;
Liberman, Daniel ;
Isbarn, Hendrik ;
Capitanio, Umberto ;
Shariat, Shahrokh F. ;
Sun, Maxine ;
Lughezzani, Giovanni ;
Perrotte, Paul ;
Montorsi, Francesco ;
Graefen, Markus ;
Karakiewicz, Pierre I. .
UROLOGY, 2009, 74 (04) :837-841
[22]   Prediction of Progression-Free Survival Rates After Bevacizumab Plus Interferon Versus Interferon Alone in Patients with Metastatic Renal Cell Carcinoma: Comparison of a Nomogram to the Motzer Criteria [J].
Karakiewicz, Pierre I. ;
Sun, Maxine ;
Bellmunt, Joaquin ;
Sneller, Vesna ;
Escudier, Bernard .
EUROPEAN UROLOGY, 2011, 60 (01) :48-56
[23]   The Role of Surgery in Advanced Renal Cell Carcinoma: Cytoreductive Nephrectomy and Metastasectomy [J].
Karam, Jose A. ;
Wood, Christopher G. .
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 2011, 25 (04) :753-+
[24]   Metastasectomy After Targeted Therapy in Patients With Advanced Renal Cell Carcinoma [J].
Karam, Jose A. ;
Rini, Brian I. ;
Varella, Leticia ;
Garcia, Jorge A. ;
Dreicer, Robert ;
Choueiri, Toni K. ;
Jonasch, Eric ;
Matin, Surena F. ;
Campbell, Steven C. ;
Wood, Christopher G. ;
Tannir, Nizar M. .
JOURNAL OF UROLOGY, 2011, 185 (02) :439-444
[25]   Surgery Insight: management of renal cell carcinoma with associated inferior vena cava thrombus [J].
Karnes, R. Jeffrey ;
Blute, Michael L. .
NATURE CLINICAL PRACTICE UROLOGY, 2008, 5 (06) :329-339
[26]   Use of systemic therapy and factors affecting survival for patients undergoing cytoreductive nephrectomy [J].
Kutikov, Alexander ;
Uzzo, Robert G. ;
Caraway, Aaron ;
Reese, Carl T. ;
Egleston, Brian L. ;
Chen, David Y. T. ;
Viterbo, Rosalia ;
Greenberg, Richard E. ;
Wong, Yu-Ning ;
Raman, Jay D. ;
Boorjian, Stephen A. .
BJU INTERNATIONAL, 2010, 106 (02) :218-223
[27]   Predictors of Survival of Advanced Renal Cell Carcinoma: Long-Term Results From Southwest Oncology Group Trial S8949 [J].
Lara, Primo N., Jr. ;
Tangen, Catherine M. ;
Conlon, Sarah J. ;
Flanigan, Robert C. ;
Crawford, E. David .
JOURNAL OF UROLOGY, 2009, 181 (02) :512-516
[28]   Radical nephrectomy plus interferon-alfa-based immunotherapy compared with interferon alfa alone in metastatic renal-cell carcinoma: a randomised trial [J].
Mickisch, GHJ ;
Garin, A ;
van Poppel, H ;
de Prijck, L ;
Sylvester, R .
LANCET, 2001, 358 (9286) :966-970
[29]   Prognostic nomogram for sunitinib in patients with metastatic renal cell carcinoma [J].
Motzer, Robert J. ;
Bukowski, Ronald M. ;
Figlin, Robert A. ;
Hutson, Thomas E. ;
Michaelson, M. Dror ;
Kim, Sindy T. ;
Baum, Charles M. ;
Kaftan, Michael W. .
CANCER, 2008, 113 (07) :1552-1558
[30]   Sunitinib versus interferon alfa in metastatic renal-cell carcinoma [J].
Motzer, Robert J. ;
Hutson, Thomas E. ;
Tomczak, Piotr ;
Michaelson, M. Dror ;
Bukowski, Ronald M. ;
Rixe, Olivier ;
Oudard, Stephane ;
Negrier, Sylvie ;
Szczylik, Cezary ;
Kim, Sindy T. ;
Chen, Isan ;
Bycott, Paul W. ;
Baum, Charles M. ;
Figlin, Robert A. .
NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (02) :115-124
12345