Comparison of psychophysical, electrophysiological, and fMRI assessment of visual contrast responses in patients with schizophrenia

被引:41
作者
Calderone, Daniel J. [1 ,2 ,3 ]
Martinez, Antigona [1 ,4 ]
Zemon, Vance [1 ,5 ]
Hoptman, Matthew J. [1 ,2 ,3 ]
Hu, George [6 ]
Watkins, Jade E. [1 ]
Javitt, Daniel C. [1 ,3 ,7 ]
Butler, Pamela D. [1 ,2 ,3 ]
机构
[1] Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA
[2] NYU, Sch Med, Dept Psychiat, New York, NY 10016 USA
[3] CUNY, Dept Psychol, Grad Ctr, New York, NY 10016 USA
[4] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
[5] Albert Einstein Coll Med, Ferkauf Grad Sch Psychol, Bronx, NY 10461 USA
[6] Verisci Corp, Raritan, NJ 08869 USA
[7] Columbia Univ Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA
关键词
Contrast sensitivity; fMRI; Gain control; Magnocellular; Schizophrenia; Visual; GAIN-CONTROL; PERCEPTUAL ORGANIZATION; SENSORY CONTRIBUTIONS; PROCESSING DEFICITS; PRIMATE RETINA; IMPAIRMENT; SENSITIVITY; RECOGNITION; DYSFUNCTION; MECHANISMS;
D O I
10.1016/j.neuroimage.2012.11.019
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Perception has been identified by the NIMH-sponsored Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) group as a useful domain for assessing cognitive deficits in patients with schizophrenia. Specific measures of contrast gain derived from recordings of steady-state visual evoked potentials (ssVEP) have demonstrated neural deficits within the visual pathways of patients with schizophrenia. Psychophysical measures of contrast sensitivity have also shown functional loss in these patients. In the current study, functional magnetic resonance imaging (fMRI) was used in conjunction with ssVEP and contrast sensitivity testing to elucidate the neural underpinnings of these deficits. During fMRI scanning, participants viewed 1) the same low and higher spatial frequency stimuli used in the psychophysical contrast sensitivity task, at both individual detection threshold contrast and at a high contrast; and 2) the same stimuli used in the ssVEP paradigm, which were designed to be biased toward either the magnocellular or parvocellular visual pathway. Patients showed significant impairment in contrast sensitivity at both spatial frequencies in the psychophysical task, but showed reduced occipital activation volume for low, but not higher, spatial frequency at the low and high contrasts tested in the magnet. As expected, patients exhibited selective deficits under the magnocellular-biased ssVEP condition. However, occipital lobe fMRI responses demonstrated the same general pattern for magnocellular- and parvocellular-biased stimuli across groups. These results indicate dissociation between the fMRI measures and the psychophysical/ssVEP measures. These latter measures appear to have greater value for the functional assessment of the contrast deficits explored here. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码:153 / 162
页数:10
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