Synthesis of spacered cyclopropyl nucleoside analogues as potential antiviral agents

被引：23

作者：

Csuk, R ^{[1
]}

Kern, A ^{[1
]}

机构：

[1] Univ Halle Wittenberg, Inst Organ Chem, D-06120 Halle, Germany

来源：

TETRAHEDRON | 1999年 / 55卷 / 28期

关键词：

cyclopropanes; nucleosides; antivirals;

D O I：

10.1016/S0040-4020(99)00467-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel spacered cyclopropane nucleoside analogues possessing both a hydroxyethyl group and an additional methylene spacer between the base and the ring were synthesized starting from 3-buten-1-ol. After tetrahydropyranylation, cyclopropanation, and reduction the target molecules were obtained by Mitsunobu reactions followed by two consecutive deprotection steps. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：8409 / 8422

页数：14

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