Enterotypes in the landscape of gut microbial community composition

被引：471

作者：

Costea, Paul I. ^{[1
]}

Hildebrand, Falk ^{[1
,2
,3
]}

Manimozhiyan, Arumugam ^{[4
]}

Backhed, Fredrik ^{[5
,6
]}

Blaser, Martin J. ^{[7
]}

Bushman, Frederic D. ^{[8
]}

de Vos, Willem M. ^{[9
,10
]}

Ehrlich, S. Dusko ^{[11
,12
]}

Fraser, Claire M. ^{[13
]}

Hattori, Masahira ^{[14
]}

Huttenhower, Curtis ^{[15
]}

Jeffery, Ian B. ^{[16
]}

Knights, Dan ^{[17
,18
]}

Lewis, James D. ^{[19
]}

Ley, Ruth E. ^{[20
]}

Ochman, Howard ^{[21
]}

O'Toole, Paul W. ^{[16
]}

Quince, Christopher ^{[22
]}

Relman, David A. ^{[23
,24
,25
]}

Shanahan, Fergus

Sunagawa, Shinichi ^{[26
]}

Wang, Jun ^{[5
,27
,28
,29
,30
,31
]}

Weinstock, George M. ^{[32
]}

Wu, Gary D. ^{[33
]}

Zeller, Georg ^{[1
]}

Zhao, Liping ^{[34
]}

Raes, Jeroen ^{[2
,3
,35
]}

Knight, Rob ^{[36
,37
,38
,39
]}

Bork, Peer ^{[40
,41
]}

机构：

[1] European Mol Biol Lab, Heidelberg, Germany

[2] VIB, VIB Ctr Microbiol, Ghent, Belgium

[3] Vrije Univ Brussel, Microbiol Lab, Brussels, Belgium

[4] Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark

[5] Univ Gothenburg, Sahlgrenska Acad, Inst Med, Wallenberg Lab,Dept Mol & Clin Med, Gothenburg, Sweden

[6] Univ Copenhagen, Fac Hlth Sci, Sect Metab Receptol & Enteroendocrinol, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark

[7] NYU, Langone Med Ctr, New York, NY USA

[8] Univ Penn, Perelman Sch Med, Dept Microbiol, Philadelphia, PA USA

[9] Univ Helsinki, Dept Bacteriol & Immunol, RPU Immunobiol, Helsinki, Finland

[10] Wageningen Univ, Microbiol Lab, Wageningen, Netherlands

[11] INRA, Metagenopolis, Jouy En Josas, France

[12] Kings Coll London, Guys Hosp, Dent Inst Cent Off, Ctr Host Microbiome Interact, London, England

[13] Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA

[14] Waseda Univ, Grad Sch Adv Sci & Engn, Tokyo, Japan

[15] Harvard Sch Publ Hlth, Dept Biostat, Boston, MA USA

[16] Univ Coll Cork, APC Microbiome Inst, Cork, Ireland

[17] Univ Minnesota, Biotechnol Inst, St Paul, MN 55108 USA

[18] Univ Minnesota, Dept Comp Sci & Engn, Minneapolis, MN USA

[19] Univ Penn, Perelman Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA USA

[20] MPI Dept Microbiome Sci, Tubingen, Germany

[21] Univ Texas Austin, Dept Integrat Biol, Austin, TX 78712 USA

[22] Univ Warwick, Warwick Med Sch, Coventry, W Midlands, England

[23] Stanford Univ, Dept Microbiol & Immunol, Stanford, CA 94305 USA

[24] Stanford Univ, Dept Med, Stanford, CA 94305 USA

[25] Veterans Affairs Palo Alto Hlth Care Syst, Palo Alto, CA USA

[26] Swiss Fed Inst Technol, Inst Microbiol, Dept Biol, Zurich, Switzerland

[27] Univ Copenhagen, Dept Biol, Copenhagen, Denmark

[28] King Abdulaziz Univ, Princess Al Jawhara Albrahim Ctr Excellence Res H, Jeddah, Saudi Arabia

[29] Macau Univ Sci & Technol, Avenida Wai Long, Taipa, Macao, Peoples R China

[30] Univ Hong Kong, Dept Med, Pokfulam, Hong Kong, Peoples R China

[31] Univ Hong Kong, State Key Lab Pharmaceut Biotechnol, Pokfulam, Hong Kong, Peoples R China

[32] Jackson Lab Genom Med, Farmington, CT USA

[33] Univ Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA USA

[34] Shanghai Jiao Tong Univ, Shanghai Ctr Syst Biomed, Minist Educ, Key Lab Syst Biomed, Shanghai, Peoples R China

[35] Katholieke Univ Leuven, Rega Inst, Dept Microbiol & Immunol, Leuven, Belgium

[36] Univ Colorado, Dept Comp Sci, Boulder, CO 80309 USA

[37] Univ Colorado, Biofrontiers Inst, Boulder, CO 80309 USA

[38] Univ Colorado, Dept Chem & Biochem, Campus Box 215, Boulder, CO 80309 USA

[39] Univ Colorado, Howard Hughes Med Inst, Boulder, CO USA

[40] Max Delbruck Ctr Mol Med, Berlin, Germany

[41] Mol Med Partnership Unit, Heidelberg, Germany

来源：

NATURE MICROBIOLOGY | 2018年 / 3卷 / 01期

基金：

英国生物技术与生命科学研究理事会; 欧洲研究理事会;

关键词：

DIET; PREVOTELLA; AGE; ASSOCIATION; BACTEROIDES; METABOLISM; DIVERSITY; ECOSYSTEM; RICHNESS; CHILDREN;

D O I：

10.1038/s41564-017-0072-8

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Population stratification is a useful approach for a better understanding of complex biological problems in human health and wellbeing. The proposal that such stratification applies to the human gut microbiome, in the form of distinct community composition types termed enterotypes, has been met with both excitement and controversy. In view of accumulated data and re-analyses since the original work, we revisit the concept of enterotypes, discuss different methods of dividing up the landscape of possible microbiome configurations, and put these concepts into functional, ecological and medical contexts. As enterotypes are of use in describing the gut microbial community landscape and may become relevant in clinical practice, we aim to reconcile differing views and encourage a balanced application of the concept.

引用

页码：8 / 16

页数：9

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