One-pot synthesis of spiropyrroloquinoline-isoindolinone and their aza-analogs via the Ugi-4CR/metal-free intramolecular bis-annulation process

被引：37

作者：

Ghandi, Mehdi ^{[1
]}

Zarezadeh, Nahid ^{[1
]}

Abbasi, Alireza ^{[1
]}

机构：

[1] Univ Tehran, Coll Sci, Sch Chem, Tehran, Iran

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 30期

关键词：

C-H ACTIVATION; DIASTEREOSELECTIVE DOMINO CYCLIZATION; RUTHENIUM-CATALYZED CYCLIZATION; DIVERSE HETEROCYCLIC SCAFFOLDS; HIGHLY EFFICIENT SYNTHESIS; UGI 4CC/S-N CYCLIZATION; MULTICOMPONENT REACTIONS; 3-SUBSTITUTED ISOINDOLINONES; STEREOSELECTIVE-SYNTHESIS; ASYMMETRIC-SYNTHESIS;

D O I：

10.1039/c5ob01095k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This presentation discloses a one-pot synthesis of a series of spiropyrroloquinoline isoindolinone and spiropyrroloquinoline aza-isoindolinone scaffolds. The reaction proceeds by the combination of a Ugi four-component reaction (4CR) and two intramolecular cyclizations under metal-free conditions. The proof of the structures relies on analytical investigation and X-ray crystallography.

引用

收藏

页码：8211 / 8220

页数：10

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