The anticancer effects of Cucurbitacin I inhibited cell growth of human non-small cell lung cancer through PI3K/AKT/p70S6K pathway

被引:19
作者
Zhu, Xueqiang [1 ]
Huang, Hui [1 ]
Zhang, Jun [2 ]
Liu, Hao [1 ]
Ao, Rui [1 ]
Xiao, Ming [1 ]
Wu, Yuelei [3 ]
机构
[1] Sichuan Prov Peoples Hosp, Ctr Oncol, Chengdu 610072, Sichuan, Peoples R China
[2] Third Peoples Hosp Chengdu, Dept Oncol, Chengdu 610031, Sichuan, Peoples R China
[3] Chengdu First Peoples Hosp, Dept Gerontol, 18 Wanxiang North Rd, Chengdu 610041, Sichuan, Peoples R China
关键词
Cucurbitacin I; non-small cell lung cancer; phosphatidylinositol-4,5-bisphosphate 3-kinase; AKT; p70S6K; PLATINUM-BASED CHEMOTHERAPY; SIGNALING PATHWAY; PI3K/AKT/MTOR PATHWAY; MAINTENANCE THERAPY; 1ST-LINE TREATMENT; KINASE; ACTIVATION; TRIAL; CHEMOSENSITIVITY; PROGRESSION;
D O I
10.3892/mmr.2017.8141
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The present study aimed to identify potential anticancer effects of Cucurbitacin I regulators on cell growth of human non-small cell lung cancer (NSCLC) and to explore their mechanism. The results indicated that the anticancer effects of Cucurbitacin I markedly attenuated cell proliferation, and induced apoptosis in NSCLC. Furthermore, Cucurbitacin I suppressed phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K), phosphorylation (p)-AKT and p-p70S6K pathway in NSCLC. Then, (PI3K) inhibitor increased anticancer effects of Cucurbitacin I on NSCLC. In conclusion, the present results indicated that Cucurbitacin I inhibited cell growth of human NSCLC through PI3K/AKT/p70S6K signaling pathway.
引用
收藏
页码:2750 / 2756
页数:7
相关论文
共 27 条
[1]   3,4-Dihydroxybenzalactone Suppresses Human Non-Small Cell Lung Carcinoma Cells Metastasis via Suppression of Epithelial to Mesenchymal Transition, ROS-Mediated PI3K/AKT/MAPK/MMP and NFκB Signaling Pathways [J].
Chao, Wei ;
Deng, Jeng-Shyan ;
Li, Pei-Ying ;
Liang, Yu-Chia ;
Huang, Guan-Jhong .
MOLECULES, 2017, 22 (04)
[2]   Trilinolein Inhibits Proliferation of Human Non-Small Cell Lung Carcinoma A549 Through the Modulation of PI3K/Akt Pathway [J].
Chou, Pei-Yu ;
Huang, Guan-Jhong ;
Pan, Chun-Hsu ;
Chien, Yi-Chung ;
Chen, Ying-Yi ;
Wu, Chieh-Hsi ;
Sheu, Ming-Jyh ;
Cheng, Hsu-Chen .
AMERICAN JOURNAL OF CHINESE MEDICINE, 2011, 39 (04) :803-815
[3]   A Phase 2 Randomized Trial of Paclitaxel and Carboplatin with or without Panitumumab for First-Line Treatment of Advanced Non-Small-Cell Lung Cancer [J].
Crawford, Jeffrey ;
Swanson, Paul ;
Schwarzenberger, Paul ;
Sandler, Alan ;
Prager, Diane ;
Zhang, Kathy ;
Freeman, Daniel J. ;
Johnson, Carol W. ;
Krishnan, Kartik ;
Johnson, David .
JOURNAL OF THORACIC ONCOLOGY, 2013, 8 (12) :1510-1518
[4]  
Dhar R, 2008, INT J ONCOL, V32, P1133
[5]   Everolimus synergizes with gefitinib in non-small-cell lung cancer cell lines resistant to epidermal growth factor receptor tyrosine kinase inhibitors [J].
Dong, Song ;
Zhang, Xu-Chao ;
Cheng, Hua ;
Zhu, Jian-Quan ;
Chen, Zhi-Hong ;
Zhang, Yi-Fang ;
Xie, Zhi ;
Wu, Yi-Long .
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2012, 70 (05) :707-716
[6]   Targeting PI3K/AKT/mTOR pathway in non small cell lung cancer [J].
Fumarola, Claudia ;
Bonelli, Mara A. ;
Petronini, Pier Giorgio ;
Alfieri, Roberta R. .
BIOCHEMICAL PHARMACOLOGY, 2014, 90 (03) :197-207
[7]   Weekly and every 2 weeks cetuximab maintenance therapy after platinum-based chemotherapy plus cetuximab as first-line treatment for non-small cell lung cancer: randomized non-comparative phase IIIb NEXT trial [J].
Heigener, David F. ;
Pereira, Jose Rodrigues ;
Felip, Enriqueta ;
Mazal, Juraj ;
Manzyuk, Lyudmila ;
Tan, Eng Huat ;
Merimsky, Ofer ;
Sarholz, Barbara ;
Esser, Regina ;
Gatzemeier, Ulrich .
TARGETED ONCOLOGY, 2015, 10 (02) :255-265
[8]   5-Caffeoylquinic acid inhibits invasion of non-small cell lung cancer cells through the inactivation of p70S6K and Akt activity: Involvement of p53 in differential regulation of signaling pathways [J].
In, Jae-Kyung ;
Kim, Jin-Kyu ;
Oh, Joa Sub ;
Seo, Dong-Wan .
INTERNATIONAL JOURNAL OF ONCOLOGY, 2016, 48 (05) :1907-1912
[9]   Cucurbitacin-I (JS']JSI-124) activates the JNK/c-Jun signaling pathway independent of apoptosis and cell cycle arrest in B Leukemic Cells [J].
Ishdorj, Ganchimeg ;
Johnston, James B. ;
Gibson, Spencer B. .
BMC CANCER, 2011, 11
[10]   Cucurbitacin I blocks cerebrospinal fluid and platelet derived growth factor-BB stimulation of leptomeningeal and meningioma DNA synthesis [J].
Johnson, Mahlon D. ;
O'Connell, Mary J. ;
Walter, Kevin .
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2013, 13