A family history of cancer and lung cancer risk in never-smokers: A clinic-based case-control study

被引:36
作者
Lin, Huan [1 ,2 ]
Huang, Yi-Sheng [1 ,2 ]
Yan, Hong-hong [1 ,2 ]
Yang, Xue-Ning [1 ,2 ]
Zhong, Wen-Zhao [1 ,2 ]
Ye, Huan-Wen [3 ]
Yang, Jin-Ji [1 ,2 ]
Zhou, Qing [1 ,2 ]
Wu, Yi-Long [1 ,2 ]
机构
[1] Guangdong Gen Hosp, Guangdong Lung Canc Inst, Guangzhou 510080, Guangdong, Peoples R China
[2] Guangdong Acad Med Sci, Guangzhou 510080, Guangdong, Peoples R China
[3] Guangdong Prov Tradit Chinese Med Hosp, Guangzhou 510000, Guangdong, Peoples R China
关键词
Familial aggregation; Lung cancer; Never-smoker; Genetics; Adenocarcinoma; Epidermal growth factor receptor; SMOKING; AGGREGATION; ASSOCIATION; RELATIVES; SIBLINGS; PARENTS; FRIENDS;
D O I
10.1016/j.lungcan.2015.05.017
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objective: Some population-based studies involving lung cancer patients have reported that inherited susceptibility is responsible for the familial aggregation observed in non-smoking lung cancer patients; however, it has been found that the false-negative rates in clinic-ascertained probands are significantly lower than population-ascertained probands. In this clinic-based study, we sought to determine the relationship between a family history of cancer and lung cancer risk in Chinese never-smokers. Methods: In this clinic-based case-control study, all 318 probands and 509 controls were Chinese. The data on demographic characteristics, age, gender, race, lung disease history, living environment, occupational exposure, and smoking history were collected from a structured questionnaire. Multiple conditional logistic regression was used to estimate adjusted odds ratios (aOR) and 95% CIs after adjusting for possible confounders. Results: The risk of lung cancer was increased in individuals with a family history of lung (aOR, 3.21; p < 0.001) or any other cancer (aOR, 1.79; p < 0.001). Analyses were carried out using stratified relative gender; first-degree female relatives tended to have a higher risk than first-degree male relatives. Similarly, the aOR for a female developing a malignant tumor was two times greater than controls. Conclusions: Our analysis provides further evidence of the importance of genetic factors underlying lung cancer in patients who are never-smokers, especially in patients with a maternal history of cancer. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:94 / 98
页数:5
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