A chemoenzymatic asymmetric synthesis of (+)-strictifolione

被引：16

作者：

Ghadigaonkar, Sneha ^{[1
]}

Koli, Mrunesh R. ^{[1
]}

Gamre, Sunita S. ^{[1
]}

Choudhary, Manoj K. ^{[1
]}

Chattopadhyay, Subrata ^{[1
]}

Sharma, Anubha ^{[1
]}

机构：

[1] Bhabha Atom Res Ctr, Div Bioorgan, Bombay 400085, Maharashtra, India

来源：

TETRAHEDRON-ASYMMETRY | 2012年 / 23卷 / 14期

关键词：

MOLECULAR-MECHANISM; OLEFIN METATHESIS; LIPASE; BIOCATALYSIS; REAGENTS; LACTONE; ESTERS;

D O I：

10.1016/j.tetasy.2012.06.015

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A chemoenzymatic asymmetric synthesis of the title compound has been developed using an efficient lipase-catalyzed acylation and a chiral reagent-directed diastereoselective allylation as the key steps for incorporating the stereogenic centers. A cross metathesis was employed to obtain the required E-olefin geometry of the target compound. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1093 / 1099

页数：7

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