Synthesis and evaluation of azaindole-α-alkyloxyphenylpropionic acid analogues as PPARα/γ agonists

被引：24

作者：

Cai, ZF

Feng, J

Guo, YS

Li, PP

Shen, ZF

Chu, FM

Guo, ZR

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 03期

关键词：

D O I：

10.1016/j.bmc.2005.09.040

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of azaindole-alpha-alkyloxyphenylpropionic acid analogues was synthesized and evaluated for PPAR agonist activities. Structure-activity relationship was developed for PPAR alpha/gamma dual agonism. One of the synthesized compound 7a was identified as a potent, selective PPAR alpha/gamma dual agonist. (c) 2005 Elsevier Ltd. All rights reserved.

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收藏

页码：866 / 874

页数：9

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