Determination of paracetamol at a graphite-polyurethane composite electrode as an amperometric flow detector

被引:21
作者
Cervini, Priscila [1 ]
Gomes Cavalheiro, Eder Tadeu [1 ]
机构
[1] Univ Sao Paulo, Inst Quim Sao Carlos, Dept Quim & Fis Mol, BR-13566390 Sao Carlos, SP, Brazil
关键词
paracetamol; graphite-PU composite electrode; FIA;
D O I
10.1590/S0103-50532008000500005
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A bare graphite-polyurethane composite was evaluated as an amperometric flow injection detector in the determination of paracetamol (APAP) in pharmaceutical formulations. A linear analytical curve was observed in the 5.00 x 10(-5) to 5.00 x 10(-3) mol L-1 range with a minimum detectable net concentration of 18.9 mu mol L-1 and 180 determinations h(-1), after optimization of parameters such as the detection potential, sample loop volume, and carrier solution flow rate. Interference of ascorbic acid was observed, however, it was possible overcome the interference, reaching results that agreed with HPLC within 95% confidence level. These results showed that the graphite-polyurethane composite can be used as an amperometric detector for flow analysis in the determination of APAP.
引用
收藏
页码:836 / 841
页数:6
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