Dual Catalytic Platform for Enabling sp3 α C-H Arylation and Alkylation of Benzamides

被引：87

作者：

Rand, Alexander W. ^{[1
]}

Yin, Hongfei ^{[3
]}

Xu, Liang ^{[3
]}

Giacoboni, Jessica ^{[3
]}

Martin-Montero, Raul ^{[3
]}

Romano, Ciro ^{[3
]}

Montgomery, John ^{[1
]}

Martin, Ruben ^{[2
,3
]}

机构：

[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

[2] ICREA, Barcelona 08010, Spain

[3] Barcelona Inst Sci & Technol, Inst Chem Res Catalonia ICIQ, Tarragona 43007, Spain

来源：

ACS CATALYSIS | 2020年 / 10卷 / 08期

基金：

美国国家科学基金会;

关键词：

sp(3) C-H activation; photocatalysis; nickel; enantioselectivity; metallaphotoredox; PHOTOREDOX CATALYSIS; FUNCTIONALIZATION; BONDS; GAMMA;

D O I：

10.1021/acscatal.0c01318

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A dual catalytic sp(3) alpha C-H arylation and alkylation of benzamides with organic halides is described. This protocol exhibits an exquisite site selectivity, chemoselectivity, and enantioselectivity pattern, offering a complementary reactivity mode to existing sp(3) arylation or alkylations via transition metal catalysis or photoredox events.

引用

页码：4671 / 4676

页数：6

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