Replication origins run (ultra) deep

被引：15
作者：
Gilbert, David M. [1 ]
机构：
[1] Florida State Univ, Dept Biol Sci, Tallahassee, FL 32306 USA
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2012年 / 19卷 / 08期
关键词：
DNA-REPLICATION; GENOME-WIDE; HUMAN-CELLS; INITIATION; REVEALS; REGIONS;
D O I：
10.1038/nsmb.2352
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The search for the holy replicator has been revitalized through ultradeep sequencing of small RNA-primed single-stranded DNA. Saturation sequencing provides an explanation for the lack of overlap in prior data sets, suggests that frequency of origin usage but not site selection is developmentally regulated, and uncovers a complex four-stranded DNA structure associated with most origins.
引用
收藏
页码：740 / 742
页数：3
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