Antibodies against domain I of β2-glycoprotein I: the one and only?

被引：22
作者：
Pelkmans, L. [1 ,2 ]
de laat, B. [1 ,2 ,3 ,4 ]
机构：
[1] Maastricht Univ, Med Ctr, Lab Pathophysiol Thrombin Generat, Dept Biochem,CARIM, Maastricht, Netherlands
[2] Synapse BV, Maastricht, Netherlands
[3] Sanquin Blood Supply Fdn, Amsterdam, Netherlands
[4] Univ Med Ctr Utrecht, Dept Clin Chem & Haematol, Utrecht, Netherlands
来源：
LUPUS | 2012年 / 21卷 / 07期
关键词：
Anticardiolipin antibodies; antiphospholipid syndrome; lupus anticoagulant; thrombosis; DEFINITE ANTIPHOSPHOLIPID SYNDROME; INTERNATIONAL CONSENSUS STATEMENT; HUMAN BETA(2)-GLYCOPROTEIN I; CLASSIFICATION CRITERIA; PHOSPHOLIPID-BINDING; CRYSTAL-STRUCTURE; TERMINAL DOMAIN; GLYCOPROTEIN-I; SYNDROME APS; THROMBOSIS;
D O I：
10.1177/0961203312437439
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The antiphospholipid syndrome (APS) is diagnosed by the occurrence of thrombosis and/or specific pregnancy morbidity. However, the diagnosis of APS is not easy and is hampered by several problems including high prevalence of clinical symptoms and high variability between different assays resulting in a high false-positive rate. Currently APS can be diagnosed for example by detecting anti-beta 2-glycoprotein I antibodies by ELISA. It has been reported that beta 2-glycoprotein I (beta 2GPI) changes its conformation from a native to an active form and thereby it opens up enabling antibodies to bind a specific epitope. We amongst others have shown that epitope glycine40-arginine43 of domain I of beta 2GPI is predominantly responsible for binding thrombosis related antibodies. Antibodies with affinity towards other epitopes have not been associated with thrombosis. Despite these results the question remains whether these domain I antibodies are the only antibodies of importance for the detection of APS. Lupus (2012) 21, 769-772.
引用
收藏
页码：769 / 772
页数：4
相关论文
共 30 条
  • [1] β2-Glycoprotein I can exist in 2 conformations: implications for our understanding of the antiphospholipid syndrome
    Agar, Cetin
    van Os, Gwendolyn M. A.
    Morgelin, Matthias
    Sprenger, Richard R.
    Marquart, J. Arnoud
    Urbanus, Rolf T.
    Derksen, Ronald H. W. M.
    Meijers, Joost C. M.
    de Groot, Philip G.
    [J]. BLOOD, 2010, 116 (08) : 1336 - 1343
  • [2] Antibodies to Domain I of β2Glycoprotein I are in close relation to patients risk categories in Antiphospholipid Syndrome (APS)
    Banzato, A.
    Pozzi, N.
    Frasson, R.
    De Filippis, V.
    Ruffatti, A.
    Bison, E.
    Padayattil, S. J.
    Denas, G.
    Pengo, V.
    [J]. THROMBOSIS RESEARCH, 2011, 128 (06) : 583 - 586
  • [3] Adhesion mechanism of human β2-glycoprotein I to phospholipids based on its crystal structure
    Bouma, B
    de Groot, PG
    van den Elsen, JMH
    Ravelli, RBG
    Schouten, A
    Simmelink, MJA
    Derksen, RHWM
    Kroon, J
    Gros, P
    [J]. EMBO JOURNAL, 1999, 18 (19) : 5166 - 5174
  • [4] Twenty-two years of failure to set up undisputed assays to detect patients with the antiphospholipid syndrome
    de Groot, Philip G.
    Derksen, Ronald H. W. M.
    de Laat, Bas
    [J]. SEMINARS IN THROMBOSIS AND HEMOSTASIS, 2008, 34 (04) : 347 - 355
  • [5] Pathogenic anti-β2-glycoprotein I antibodies recognize domain I of β2-glycoprotein I only after a conformational change
    de Laat, B
    Derksen, RHWM
    van Lummel, M
    Pennings, MTT
    de Groot, PG
    [J]. BLOOD, 2006, 107 (05) : 1916 - 1924
  • [6] IgG antibodies that recognize epitope Gly40-Arg43 in domain I of β2-glycoprotein I cause LAC, and their presence correlates strongly with thrombosis
    de Laat, B
    Derksen, RHWM
    Urbanus, RT
    de Groot, PG
    [J]. BLOOD, 2005, 105 (04) : 1540 - 1545
  • [7] The association between circulating antibodies against domain I of beta2-glycoprotein I and thrombosis: an international multicenter study
    De Laat, B.
    Pengo, V.
    Pabinger, I.
    Musial, J.
    Voskuyl, A. E.
    Bultink, I. E. M.
    Ruffatti, A.
    Rozman, B.
    Kveder, T.
    De Moerloose, P.
    Boehlen, F.
    Rand, J.
    Ulcova-Gallova, Z.
    Mertens, K.
    De Groot, P. G.
    [J]. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2009, 7 (11) : 1767 - 1773
  • [8] Immune responses against domain I of β2-glycoprotein I are driven by conformational changes: Domain I of β2-glycoprotein I harbors a cryptic immunogenic epitope
    de Laat, Bas
    van Berkel, Miranda
    Urbanus, Rolf T.
    Siregar, Berdien
    de Groot, Philip G.
    Gebbink, Martijn F.
    Maas, Coen
    [J]. ARTHRITIS AND RHEUMATISM, 2011, 63 (12): : 3960 - 3968
  • [9] Association between beta2-glycoprotein I plasma levels and the risk of myocardial infarction in older men
    de Laat, Bas
    de Groot, Philip G.
    Derksen, Ronald H. W. M.
    Urbanus, Rolf T.
    Mertens, Koen
    Rosendaal, Frits R.
    Doggen, Carine J. M.
    [J]. BLOOD, 2009, 114 (17) : 3656 - 3661
  • [10] β2-glycoprotein I, the playmaker of the antiphospholipid syndrome
    de Laat, HB
    Derksen, RHWM
    de Groot, PG
    [J]. CLINICAL IMMUNOLOGY, 2004, 112 (02) : 161 - 168
123