Clinical value of immunohistochemically detected lymphovascular space invasion in early stage cervical carcinoma

被引:28
作者
Lim, Chung Sim [1 ]
Alexander-Sefre, Farhad [2 ]
Allam, Mohamed [3 ]
Singh, Naveena [4 ]
Aleong, Joanne Chin [4 ]
Al-Rawi, Haytham [1 ]
Jacobs, Ian J. [5 ]
机构
[1] St Bartholomews & Royal London Sch Med & Dent, Canc Res United Kingdom Translat Oncol Lab, London EC1M 6BQ, England
[2] Glasgow Royal Infirm, Glasgow G4 0SF, Lanark, Scotland
[3] Wishaw Gen Hosp, Wishaw ML2 0DP, Scotland
[4] St Bartholomews & Royal London Sch Med & Dent, Dept Pathol, London EC1A 7BE, England
[5] UCL, Inst Womens Hlth, London WC1E 6DH, England
关键词
cervical cancer; LVSI; vascular invasion; immunohistochemistry;
D O I
10.1245/s10434-008-0014-z
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: This study investigates the clinical significance of lymphovascular space invasion (LVSI) as detected by hematoxylin and eosin (LVSI-H&E) and immunohistochemistry (LVSI-IHC) in early stage cervical carcinoma. Methods: Single representative sections from 97 patients with early stage squamous cell cervical cancer were immunostained with pancytokeratin and CD31 endothelial cell marker antibodies. The H&E sections and their corresponding immunostained sections were reexamined to identify LVSI. Associations between LVSI with clinicopathological factors were sought. Results: Overall, LVSI was present in 29 (29.9%) and absent in 68 (70.1%) by IHC, as compared with 18 cases (18.6%) and 79 cases (81.4%), respectively, by H&E. Statistical analysis revealed a significant association between LVSI-H&E and nodal metastasis (P = .004). Follow-up data were available for 76 patients. The median follow-up period was 64 months. During follow-up, 7 of 24 patients with recurrent disease had evidence of LVSI-H&E as opposed to 3 of 52 cases with no recurrence. There was a significant association between tumor recurrence and LVSI-H&E (P = .009). The 5-year recurrence-free survival was 30% for the group with LVSI-H&E compared with 73% without. There was a significant difference in the recurrence-free survival between the two groups (P = .002). In contrast LVSI-IHC was found to be associated with no pathological factors, and survival analysis revealed no statistically significant association with recurrence or survival. Conclusion: LVSI-H&E in early stage cervical cancer remains an important predictive factor of recurrent disease and reduced disease-free interval. Immunohistochemically detected LVSI is a common event and seems to be of no clinical value.
引用
收藏
页码:2581 / 2588
页数:8
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