Linking the SWI/SNF complex to prostate cancer

被引：42

作者：

Lee, Ryan S. ^{[1
,2
]}

Roberts, Charles W. M. ^{[1
,2
]}

机构：

[1] Boston Childrens Hosp, Dana Farber Canc Inst, Dept Pediat Oncol, Div Hematol Oncol, Boston, MA USA

[2] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

来源：

NATURE GENETICS | 2013年 / 45卷 / 11期

关键词：

PROGRESSION;

D O I：

10.1038/ng.2805

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genes encoding subunits of the SWI/SNF chromatin-remodeling complex constitute, collectively, one of the most frequently mutated targets in cancer. Although mutations in SWI/SNF genes are uncommon in prostate cancer, a new study shows that SChLAP1, a long noncoding RNA frequently expressed in aggressive prostate tumors, drives cancer by directly disrupting SNF5, a core subunit of the SWI/SNF complex.

引用

页码：1268 / 1269

页数：2

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