Production of lovastatin and itaconic acid by Aspergillus terreus: a comparative perspective

被引：40

作者：

Boruta, Tomasz ^{[1
]}

Bizukojc, Marcin ^{[1
]}

机构：

[1] Lodz Univ Technol, Dept Bioproc Engn, Fac Proc & Environm Engn, Ul Wolczanska 213, PL-90924 Lodz, Poland

来源：

WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY | 2017年 / 33卷 / 02期

关键词：

Aspergillus terreus; Itaconic acid; Lovastatin; Metabolites; ATCC; 20542; SECONDARY METABOLISM; BIOTECHNOLOGICAL PRODUCTION; FUNGAL MORPHOLOGY; USTILAGO-MAYDIS; BIOSYNTHESIS; BATCH; OXYGEN; RHEOLOGY; FERMENTATION;

D O I：

10.1007/s11274-017-2206-9

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aspergillus terreus is a textbook example of an industrially relevant filamentous fungus. It is used for the biotechnological production of two valuable metabolites, namely itaconic acid and lovastatin. Itaconic acid serves as a precursor in polymer industry, whereas lovastatin found its place in the pharmaceutical market as a cholesterol-lowering statin drug and a precursor for semisynthetic statins. Interestingly, their biosynthetic gene clusters were shown to reside in the common genetic neighborhood. Despite the genomic proximity of the underlying biosynthetic genes, the production of lovastatin and itaconic acid was shown to be favored by different factors, especially with respect to pH values of the broth. While there are several reviews on various aspects of lovastatin and itaconic acid production, the survey on growth conditions, biochemistry and morphology related to the formation of these two metabolites has never been presented in the comparative manner. The aim of the current review is to outline the correlations and contrasts with respect to process-related and biochemical discoveries regarding itaconic acid and lovastatin production by A. terreus.

引用

页数：12

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