Osteogenesis Catalyzed by Titanium-Supported Silver Nanoparticles

被引：64

作者：

Cao, Huiliang ^{[1
]}

Zhang, Wenjie ^{[2
]}

Meng, Fanhao ^{[1
]}

Guo, Jinshu ^{[1
]}

Wang, Donghui ^{[1
]}

Qian, Shi ^{[1
]}

Jiang, Xinquan ^{[2
]}

Liu, Xuanyong ^{[1
]}

Chu, Paul K. ^{[3
]}

机构：

[1] Chinese Acad Sci, State Key Lab High Performance Ceram & Superfine, Shanghai Inst Ceram, Shanghai 200050, Peoples R China

[2] Shanghai Jiao Tong Univ, Peoples Hosp 9, Sch Med, Dept Prosthodont, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China

[3] City Univ Hong Kong, Dept Phys & Mat Sci, Tat Chee Ave, Kowloon, Hong Kong, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2017年 / 9卷 / 06期

基金：

中国国家自然科学基金; 美国国家科学基金会;

关键词：

silver; integrin; differentiation; osteointegration; titanium; stem cells; MESENCHYMAL STEM-CELLS; OSTEOBLAST DIFFERENTIATION; GALVANIC CORROSION; INTEGRIN; OSSEOINTEGRATION; ADHESION; BIOMATERIALS; INFECTION; IMPLANTS; SURFACES;

D O I：

10.1021/acsami.6b15448

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Silver nanoparticles (Ag NPs) were widely explored for antimicrobial applications, whereas the translation into drugs and implantable antibacterial devices provoked serious concerns about their potential cytotoxicity. Herein, Ag NPs with diameters ranging from 4 to 19 nm were in situ fabricated and immobilized on titanium by using a plasma immersion ion implantation process. The particles have a population-dependent capability in activating the integrin alpha 5 orchestrated MAPK/ERK signal cascade of osteoblast differentiation in rat bone marrow stem cells (BMSCs), and promoting osteointegration of titanium. It was demonstrated that the titanium-supported Ag NPs played an important role in motivating integrin a5 through triggering the galvanic hydrogen evolution reactions, which was found in positive correlation with the distribution density of the immobilized Ag NPs. Since cellular uptake is a key factor determining the cytotoxic performance of Ag NPs, the extracellular effects of immobilized Ag NPs on promoting osteogenesis provided new insights into the safe application of nanomaterials, and into designing and developing renewed antibacterial devices with selective toxicity.

引用

页码：5149 / 5157

页数：9

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