Direct Effects of D-Chiro-Inositol on Insulin Signaling and Glucagon Secretion of Pancreatic Alpha Cells

被引：11
|
作者：
Filippello, Agnese [1 ]
Scamporrino, Alessandra [1 ]
Di Mauro, Stefania [1 ]
Malaguarnera, Roberta [2 ]
Di Pino, Antonino [1 ]
Scicali, Roberto [1 ]
Purrello, Francesco [1 ]
Piro, Salvatore [1 ]
机构：
[1] Univ Catania, Garibaldi Nesima Hosp, Dept Clin & Expt Med, Internal Med, I-95122 Catania, Italy
[2] Kore Univ Enna, Sch Human & Social Sci, I-94100 Enna, Italy
来源：
BIOMOLECULES | 2020年 / 10卷 / 10期
关键词：
alpha-cells; D-chiro-inositol; lipotoxicity; insulin resistance; ASSAYS; HYPERGLYCEMIA; HYPOGLYCEMIA; MECHANISMS; VIABILITY; MODELS; ISLETS; MTT;
D O I：
10.3390/biom10101404
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The insulin resistance state of pancreatic alpha-cells seems to be related to glucagon hypersecretion in type 2 diabetes. Treatment that can improve the insulin sensitivity of alpha-cells could control glucagon levels in patients with diabetes mellitus. The aim of this study was to investigate the preventive role of D-chiro-inositol (DCI), which has insulin receptor-sensitizer effects on insulin signaling pathways and glucagon secretion in pancreatic alpha-TC1 clone 6 cells. Cells were chronically treated with palmitate to induce insulin resistance in the presence/absence of DCI. DCI treatment improved the insulin signaling pathway and restored insulin-mediated glucagon suppression in alpha-TC1-6 cells exposed to palmitate. These results indicate that DCI treatment prevents the insulin resistance of alpha-TC1-6 cells chronically exposed to palmitate. Our data provide evidence that DCI could be useful to improve the insulin sensitivity of pancreatic alpha-cells in diabetes treatment.
引用
收藏
页码：1 / 15
页数：15
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