Killing Tumors by Keeping Ras and PI3′ Kinase Apart

被引：6

作者：

Yuan, Tina L. ^{[1
]}

McCormick, Frank ^{[1
]}

机构：

[1] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94158 USA

来源：

CANCER CELL | 2013年 / 24卷 / 05期

关键词：

PHOSPHOINOSITIDE; 3-KINASE; ACTIVATION; GTPASES; RECEPTOR; BINDING; KRAS;

D O I：

10.1016/j.ccr.2013.10.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ras proteins mediate PI3K activation through direct binding to p110 catalytic subunits. However, it is unclear when and where this interaction occurs. In this issue of Cancer Cell, Castellano and colleagues report that KRAS-driven lung cancers require the Ras-p110 alpha interaction for full activation of PI3K and tumor maintenance.

引用

页码：562 / 563

页数：2

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