Cancer stem cells, epithelial-mesenchymal transition, and drug resistance in high-grade ovarian serous carcinoma

被引：56
作者：
Chen, Xiaoxiang [1 ,2 ,3 ]
Zhang, Jing [4 ]
Zhang, Zhihong [5 ]
Li, Hongxia [5 ]
Cheng, Wenjun [6 ]
Liu, Jinsong [3 ,5 ]
机构：
[1] Nanjing Med Univ, Affiliated Canc Hosp, Jiangsu Canc Hosp, Dept Gynecol Oncol, Nanjing 210029, Jiangsu, Peoples R China
[2] Southeast Univ, State Key Lab Bioelect, Nanjing 210096, Jiangsu, Peoples R China
[3] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA
[4] Fourth Mil Med Univ, Dept Pathol, Xian 710032, Shanxi, Peoples R China
[5] Nanjing Med Univ, Affiliated Hosp 1, Dept Pathol, Nanjing 210029, Jiangsu, Peoples R China
[6] Nanjing Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Nanjing 210029, Jiangsu, Peoples R China
来源：
HUMAN PATHOLOGY | 2013年 / 44卷 / 11期
基金：
美国国家卫生研究院;
关键词：
High-grade ovarian serous cancer; Cancer stem cell; Epithelial-mesenchymal transition; SIDE-POPULATION CELLS; TGF-BETA; CD133; EXPRESSION; PROSPECTIVE IDENTIFICATION; ALDEHYDE DEHYDROGENASE; PROGNOSTIC FACTORS; POOR-PROGNOSIS; TUMOR-GROWTH; PHENOTYPE; EMT;
D O I：
10.1016/j.humpath.2013.05.001
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Although epithelial ovarian cancer cells are eliminated by debulking surgery and chemotherapy during initial treatment, it is believed that only a subset of cancer cells, that is, cancer stem cells, may be an important source of tumor recurrence and drug resistance. This review highlights our current understanding of high-grade serous carcinoma, ovarian cancer stem cells, common methods for enrichment of ovarian cancer stem cells, mechanisms involved in drug resistance, and potential strategies for overcoming drug resistance, with associated potential controversies and pitfalls. We also review the potential relationship between epithelial-to-mesenchymal transition and cancer stem cells and how we can induce cancer cells to differentiate into benign stromal fibroblasts in response to certain chemotherapy drugs. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码：2373 / 2384
页数：12
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