A New Antiarrhythmic Drug in the Treatment of Recent-Onset Atrial Fibrillation: Vernakalant

被引：7

作者：

Vizzardi, Enrico ^{[1
]}

Salghetti, Francesca ^{[1
]}

Bonadei, Ivano ^{[1
]}

Gelsomino, Sandro ^{[2
]}

Lorusso, Roberto ^{[3
]}

D'Aloia, Antonio ^{[1
]}

Curnis, Antonio ^{[1
]}

机构：

[1] Univ Brescia, Sect Cardiovasc Dis, Dept Expt & Appl Med, Brescia, Italy

[2] Careggi Hosp, Heart & Vessels Dept, Florence, SC USA

[3] Civ Hosp, Cardiac Surg Unit, Expt Cardiac Surg Lab, Brescia, Italy

来源：

CARDIOVASCULAR THERAPEUTICS | 2013年 / 31卷 / 05期

关键词：

Atrial fibrillation; Vernakalant; Cardioversion; RAPID CONVERSION; SINUS RHYTHM; EFFICACY; IBUTILIDE; SAFETY; FLUTTER; CARDIOVERSION; AMIODARONE; HYDROCHLORIDE; PROPAFENONE;

D O I：

10.1111/1755-5922.12026

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Summary Vernakalant is a new antiarrhythmic agent recently approved in Europe for the rapid cardioversion of recent-onset atrial fibrillation. It works by blocking early-activating K+ atrial channels and frequency-dependent atrial Na+ channels, prolonging atrial refractory periods and rate-dependent slowing atrial conduction, without promoting ventricular arrhythmia. Preclinical and clinical trials showed good toleration of this drug. The main purpose of our review is to describe all the trials that led to the incorporation of vernakalant into the current European atrial fibrillation guidelines.

引用

页码：e55 / e62

页数：8

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