Evaluation of enzyme-based tear glucose electrochemical sensors over a wide range of blood glucose concentrations

被引：72

作者：

Peng, Bo ^{[1
]}

Lu, Jing ^{[2
]}

Balijepalli, Anant S. ^{[3
]}

Major, Terry C. ^{[4
]}

Cohan, Bruce E. ^{[5
]}

Meyerhoff, Mark E. ^{[1
]}

机构：

[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Dept Surg, Ann Arbor, MI 48109 USA

[5] EyeLab Grp, Ann Arbor, MI 48109 USA

来源：

BIOSENSORS & BIOELECTRONICS | 2013年 / 49卷

关键词：

Tear glucose; Electrochemical sensor; Rabbit model; Blood-tear glucose correlation; DIABETES-MELLITUS; FLUID; COMPLICATIONS; ACCURACY; DYNAMICS;

D O I：

10.1016/j.bios.2013.05.014

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Miniature enzyme-based amperometric and coulometric glucose sensors were fabricated and applied to measure tear glucose concentrations in anesthetized rabbits. Without perturbing the eyeball, 3 mu L of tear fluid was sampled from the marginal conjunctiva under the lower eyelid of anesthetized rabbits at various time points via a microliter glass capillary tube, and the miniature sensors were then inserted into the volume of collected tear fluids within the capillaries for detection. Intravenous bolus doses of insulin were administrated to the rabbits to lower the elevated blood glucose concentrations caused by anesthesia over the 7 h test periods. A significant correlation was found between tear and blood glucose levels for multiple rabbits, suggesting that electrochemical sensor-based tear glucose measurements may be a potential supplementary method for point-of-care glucose monitoring. (C) 2013 Elsevier B.V. All rights reserved.

引用

收藏

页码：204 / 209

页数：6

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