Update on opsoclonus-myoclonus syndrome in adults

被引：79

作者：

Oh, Sun-Young ^{[1
,2
]}

Kim, Ji-Soo ^{[3
,4
]}

Dieterich, Marianne ^{[5
,6
,7
]}

机构：

[1] Chonbuk Natl Univ, Dept Neurol, Sch Med, 20 Geonji Ro, Jeonju 561712, South Korea

[2] Chonbuk Natl Univ, Res Inst Clin Med, Biomed Res Inst, Chonbuk Natl Univ Hosp, Jeonju, South Korea

[3] Seoul Natl Univ, Coll Med, Dept Neurol, Seoul, South Korea

[4] Seoul Natl Univ, Bundang Hosp, Clin Neurosci Ctr, Dept Neurol,Dizziness Ctr, Seoul, South Korea

[5] Ludwig Maximilians Univ Munchen, Dept Neurol, Munich, Germany

[6] Ludwig Maximilians Univ Munchen, German Ctr Vertigo & Balance Disorders IFBLMU, Munich, Germany

[7] Munich Cluster Syst Neurol SyNergy, Munich, Germany

来源：

JOURNAL OF NEUROLOGY | 2019年 / 266卷 / 06期

关键词：

Opsoclonus-myoclonus syndrome; Autoimmune; Encephalitis; Paraneoplastic; Antibodies; ACTIVATING FACTOR BAFF; PARANEOPLASTIC OPSOCLONUS; ATAXIA SYNDROME; B-CELL; ANTI-RI; ANTINEURONAL ANTIBODIES; NEUROBLASTOMA; AUTOANTIBODIES; CHILDREN; DISORDERS;

D O I：

10.1007/s00415-018-9138-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Opsoclonus-myoclonus syndrome in adults is a rare and heterogeneous disorder with the clinical features of opsoclonus, myoclonus, ataxia, and behavioral and sleep disturbances. The pathophysiology is thought to be immunological on the basis of paraneoplastic or infectious etiologies. Immunomodulatory therapies should be performed although the response may be incomplete. A number of autoantibodies have been identified against a variety of antigens, but no diagnostic immunological marker has yet been identified. This review focuses on underlying mechanisms of opsoclonus-myoclonus syndrome, including findings that have been identified recently, and provides an update on the clinical features and treatments of this condition.

引用

页码：1541 / 1548

页数：8

共 93 条

[1] OPSOCLONUS, MYOCLONUS, ATAXIA, AND ENCEPHALOPATHY IN ADULTS WITH CANCER - A DISTINCT PARA-NEOPLASTIC SYNDROME [J].