Candida albicans in celiac disease: A wolf in sheep's clothing

被引：14
作者：
Aaron, Lerner [1 ]
Torsten, Matthias [1 ]
机构：
[1] KIPP Inst, AESKU, Wendelsheim, Germany
来源：
AUTOIMMUNITY REVIEWS | 2020年 / 19卷 / 09期
关键词：
Celiac disease; Candida albicans; Transglutaminase; Gluten; Hwp1; Sequence homology; Shared antibodies; Cross reactivity; DUODENAL MICROBIOTA COMPOSITION; COMMENSAL FUNGI; CELL-WALL; TRANSGLUTAMINASE; ANTIBODIES; DYSBIOSIS; RESPONSES; SUSCEPTIBILITY; COLONIZATION; AUTOIMMUNE;
D O I：
10.1016/j.autrev.2020.102621
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Candida albicans is a commensal fungus with a potential pathogenicity and celiac disease is an autoimmune condition. Both share multiple pathophysiological junctions, including serological markers against cell-wall proteins of Candida, anti-gliadin antibodies are positive in both entities, gluten and a candidal virulence factor share sequence similarity and the autoantigen of celiac disease, the tissue transglutaminase, is pivotal in Candida albicans commensalism and hostile behavior and its covalently cross linked products are stable and resistant to breakdown in the two entities. Those autoimmune/infectious cross roads are the basis for the hypothesis that Candida albicans is an additional environmental factor for celiac disease autoimmunogenesis.
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页数：7
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