Development of liposomal formulations to potentiate natural lovastatin inhibitory activity towards 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase

被引：24
作者：
Leone, Gemma [1 ,2 ]
Consumi, Marco [1 ,2 ]
Franzi, Claudia [1 ]
Tamasi, Gabriella [1 ,3 ]
Lamponi, Stefania [1 ,2 ]
Donati, Alessandro [1 ,3 ]
Magnani, Agnese [1 ,2 ]
Rossi, Claudio [1 ,3 ,4 ]
Bonechi, Claudia [1 ,3 ]
机构：
[1] Univ Siena, Dept Biotechnol Chem & Pharm, Via A Moro 2, I-53100 Siena, Italy
[2] Natl Interuniv Consortium Mat Sci & Technol INSTM, Via G Giusti 9, I-50121 Florence, Italy
[3] Ctr Colloid & Surface Sci CSGI, Via Lastruccia 3, I-50019 Sesto Fiorentino, Italy
[4] Univ Siena, Operat Unit, Calabria, Italy
来源：
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2018年 / 43卷
关键词：
Liposomes; Lovastatin; Red Yeast Rice; HMG-CoA; RED YEAST RICE; PHYSICOCHEMICAL CHARACTERIZATION; SKIN PERMEATION; RELEASE; DRUG; FOOD; MICROENCAPSULATION; DYSLIPIDEMIA; CARRIERS;
D O I：
10.1016/j.jddst.2017.09.019
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Liposomal formulations were obtained mixing 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and 1,2-dioleoyl- sn-glycero-3-phosphoethanolamine (DOPE) with synthetic lovastatin or lovastatin extracted from Red Yeast Rice (RYR) to prepare a vehicle able to overcome both the disadvantage of lovastatin, i. e its poor oral bioavailability and side effects. Liposomal formulation obtained combining DOPC, DOPE and hydro-alcoholic extract of RYR showed optimal physico-chemical, mechanical and thermal characteristics and the strongest inhibition activity versus 3-hydroxy-3-Methyl glutaryl coenzyme A (HMG-CoA) reductase.
引用
收藏
页码：107 / 112
页数：6
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