Advances in nanotechnology for the management of coronary artery disease

被引：43
作者：
Rhee, June-Wha [1 ]
Wu, Joseph C. [1 ,2 ,3 ,4 ]
机构：
[1] Stanford Univ, Sch Med, Dept Med, Div Cardiol, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, MIPS, Dept Radiol, Stanford, CA 94305 USA
[3] Stanford Univ, Sch Med, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA
[4] Stanford Univ, Sch Med, Cardiovasc Inst, Stanford, CA 94305 USA
来源：
TRENDS IN CARDIOVASCULAR MEDICINE | 2013年 / 23卷 / 02期
关键词：
IN-STENT RESTENOSIS; TARGETED FUMAGILLIN NANOPARTICLES; CHOLESTEROL-FED RABBITS; ATHEROSCLEROTIC LESIONS; NEOINTIMAL FORMATION; VASCULAR GRAFTS; DRUG-DELIVERY; PACLITAXEL; NANOMEDICINE; FORMULATION;
D O I：
10.1016/j.tcm.2012.08.009
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Nanotechnology holds tremendous potential to advance the current treatment of coronary artery disease. Nanotechnology may assist medical therapies by providing a safe and efficacious delivery platform for a variety of drugs aimed at modulating lipid disorders, decreasing inflammation and angiogenesis within atherosclerotic plaques, and preventing plaque thrombosis. Nanotechnology may improve coronary stent applications by promoting endothelial recovery on a stent surface utilizing bio-mimetic nanofibrous scaffolds, and also by preventing in-stent restenosis using nanoparticle-based delivery of drugs that are decoupled from stents. Additionally, nanotechnology may enhance tissue-engineered graft materials for application in coronary artery bypass grafting by facilitating cellular infiltration and remodeling of a graft matrix. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码：39 / 45
页数：7
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