La(OTf)3 catalyzed synthesis of α-aryl tetrasubstituted pyrroles through [4+1] annulation under microwave irradiation

被引：16

作者：

Tan, Xue-Min ^{[1
]}

Lai, Qiao-Mei ^{[1
]}

Yang, Zhi-Wei ^{[1
]}

Long, Xiao ^{[1
]}

Zhou, Hai-Lin ^{[1
]}

You, Xiao-Lin ^{[1
]}

Jiang, Xiao-Jie ^{[1
]}

Cui, Hai-Lei ^{[1
]}

机构：

[1] Chongqing Univ Arts & Sci, Int Acad Targeted Therapeut & Innovat, 319 Honghe Ave, Chongqing 402160, Peoples R China

来源：

TETRAHEDRON LETTERS | 2017年 / 58卷 / 02期

基金：

美国国家科学基金会;

关键词：

Annulation; Alkyne; Tetrasubstituted pyrrole; Microwave; Pentasubstituted pyrrole; HIGHLY SUBSTITUTED PYRROLES; POLYSUBSTITUTED PYRROLES; 1,3-DICARBONYL COMPOUNDS; PROPARGYLIC ALCOHOLS; MULTISUBSTITUTED PYRROLES; CHEMOSELECTIVE SYNTHESIS; EFFICIENT SYNTHESIS; CASCADE REACTIONS; TERMINAL ALKYNES; MODULAR APPROACH;

D O I：

10.1016/j.tetlet.2016.11.122

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A La(OTf)(3) catalyzed synthesis of tetrasubstituted pyrroles under microwave irradiation has been developed affording various alpha-aryl tetrasubstituted pyrroles in acceptable to good yields (36-82% yield) through condensation/alkyne azacyclization/isomerization sequence. Functionalized alpha-aryl pentasubstituted pyrroles could be prepared from tetrasubstituted pyrroles through easy transformations. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：163 / 167

页数：5

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