La(OTf)3 catalyzed synthesis of α-aryl tetrasubstituted pyrroles through [4+1] annulation under microwave irradiation

被引：16
|
作者：
Tan, Xue-Min [1 ]
Lai, Qiao-Mei [1 ]
Yang, Zhi-Wei [1 ]
Long, Xiao [1 ]
Zhou, Hai-Lin [1 ]
You, Xiao-Lin [1 ]
Jiang, Xiao-Jie [1 ]
Cui, Hai-Lei [1 ]
机构：
[1] Chongqing Univ Arts & Sci, Int Acad Targeted Therapeut & Innovat, 319 Honghe Ave, Chongqing 402160, Peoples R China
来源：
TETRAHEDRON LETTERS | 2017年 / 58卷 / 02期
基金：
美国国家科学基金会;
关键词：
Annulation; Alkyne; Tetrasubstituted pyrrole; Microwave; Pentasubstituted pyrrole; HIGHLY SUBSTITUTED PYRROLES; POLYSUBSTITUTED PYRROLES; 1,3-DICARBONYL COMPOUNDS; PROPARGYLIC ALCOHOLS; MULTISUBSTITUTED PYRROLES; CHEMOSELECTIVE SYNTHESIS; EFFICIENT SYNTHESIS; CASCADE REACTIONS; TERMINAL ALKYNES; MODULAR APPROACH;
D O I：
10.1016/j.tetlet.2016.11.122
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A La(OTf)(3) catalyzed synthesis of tetrasubstituted pyrroles under microwave irradiation has been developed affording various alpha-aryl tetrasubstituted pyrroles in acceptable to good yields (36-82% yield) through condensation/alkyne azacyclization/isomerization sequence. Functionalized alpha-aryl pentasubstituted pyrroles could be prepared from tetrasubstituted pyrroles through easy transformations. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：163 / 167
页数：5
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